Literature DB >> 6110703

The effect of catecholamine receptor antagonists on ethanol-induced locomotor stimulation.

S Liljequist, U Berggren, J Engel.   

Abstract

The effect of various catecholamine receptor antagonists, which differ in their potency to block central dopamine and noradrenaline receptors, respectively, on ethanol-induced locomotor stimulation was investigated. It was shown that small doses of both specific dopamine (pimozide, haloperidol) and noradrenaline (phenoxybenzamine, yohimbine) receptor blocking agents statistically significantly suppressed the ethanol-induced locomotor stimulation. Of special interest in this study was the observation that remarkably small doses of clozapine completely antagonized the ethanol-induced locomotor stimulation. The possibility that this effect of clozapine is mediated via its interference with the activity of central noradrenaline and/or GABA neurons is discussed.

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Year:  1981        PMID： 6110703     DOI： 10.1007/bf01254914

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  14 in total

1.  Effect of acute ethanol or acetaldehyde administration on the uptake, release, metabolism and turnover rate of norepinephrine in rat brain.

Authors:  P V Thadani; E B Truitt
Journal:  Biochem Pharmacol       Date:  1977-06-15       Impact factor: 5.858

2.  Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents.

Authors:  N E Andén; M Grabowska; U Strömbom
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

3.  Antagonism by DL-threo-DOPS of the suppression of a conditioned avoidance response induced by a dopamine-beta-hydroxylase inhibitor.

Authors:  S Ahlenius; J Engel
Journal:  J Neural Transm       Date:  1973       Impact factor: 3.575

4.  On the significance of central noradrenaline for motor activity: experiments with a new dopamine beta-hydroxylase inhibitor.

Authors:  T H Svensson; B Waldeck
Journal:  Eur J Pharmacol       Date:  1969-09       Impact factor: 4.432

5.  Suppression by alpha-methyltyrosine of ethanol-induced locomotor stimulation: partial reversal by L-dopa.

Authors:  J Engel; U Strömbom; T H Svensson; B Waldeck
Journal:  Psychopharmacologia       Date:  1974-07-11

6.  Suppression of ethanol-induced locomotor stimulation by GABA-like drugs.

Authors:  J Cott; A Carlsson; J Engel; M Lindqvist
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-12       Impact factor: 3.000

7.  The effect of lithium on amphetamine-induced locomotor stimulation.

Authors:  U Berggren; L Tallstedt; S Ahlenius; J Engel
Journal:  Psychopharmacology (Berl)       Date:  1978-09-15       Impact factor: 4.530

8.  Effect of intraperitoneally administered GABA on the locomotor activity of mice.

Authors:  B Biswas; A Carlsson
Journal:  Psychopharmacology (Berl)       Date:  1978-09-15       Impact factor: 4.530

9.  Brain concentrations of biogenic amine metabolites in acutely treated and ethanol-dependent rats.

Authors:  F Karoum; R J Wyatt; E Majchrowicz
Journal:  Br J Pharmacol       Date:  1976-04       Impact factor: 8.739

Review 10.  The effect of chronic ethanol administration on central neurotransmitter mechanisms.

Authors:  S Liljequist; J Engel
Journal:  Med Biol       Date:  1979-08
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  15 in total

1.  Habituation to test procedure modulates the involvement of dopamine D2- but not D1-receptors in ethanol-induced locomotor stimulation in mice.

Authors:  Raúl Pastor; Marta Miquel; Carlos M G Aragon
Journal:  Psychopharmacology (Berl)       Date:  2005-10-19       Impact factor: 4.530

2.  Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.

Authors:  S Liljequist; J Engel
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

3.  Differential effects of catecholamine antagonists on ethanol-induced excitation in mice.

Authors:  U M Koechling; B R Smith; Z Amit
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

4.  Dopamine antagonist effects on locomotor activity in naive and ethanol-treated FAST and SLOW selected lines of mice.

Authors:  E H Shen; J C Crabbe; T J Phillips
Journal:  Psychopharmacology (Berl)       Date:  1995-03       Impact factor: 4.530

5.  Environmental variables differentially affect ethanol-stimulated activity in selectively bred mouse lines.

Authors:  J C Crabbe; C M Deutsch; B R Tam; E R Young
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

6.  Bromocriptine and quinpirole, but not 7-OH-DPAT or SKF 38393, potentiate the inhibitory effect of L-NAME on ethanol-induced locomotor activity in mice.

Authors:  I Tayfun Uzbay; Hakan Kayir
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-02-21       Impact factor: 3.000

7.  Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats.

Authors:  L A Hilakivi; D Stenberg; J D Sinclair; K Kiianmaa
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

8.  Haloperidol prevents ethanol-stimulated locomotor activity but fails to block sensitization.

Authors:  J Broadbent; N J Grahame; C L Cunningham
Journal:  Psychopharmacology (Berl)       Date:  1995-08       Impact factor: 4.530

9.  Lack of relation between drug-seeking behavior in an addiction model and the expression of behavioral sensitization in response to ethanol challenge in mice.

Authors:  A F Ribeiro; G Pigatto; F O Goeldner; J F Lopes; R B de Lacerda
Journal:  J Neural Transm (Vienna)       Date:  2007-12-18       Impact factor: 3.575

10.  Evidence that genetic differences in habituation and GABAergic mechanisms may be related to sensitivity to ethanol and development of ethanol tolerance in mice.

Authors:  S Liljequist
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530
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