| Literature DB >> 6110599 |
T Chiba, S Kadowaki, T Taminato, H Abe, K Chihara, S Matsukura, Y Goto, Y Seino, T Fujita.
Abstract
Both the release and the content of gastric somatostatin were investigated in streptozotocin-diabetic rats. Fundic and antral somatostatin contents were both increased in streptozotocin-diabetic rats compared with control animals. Basal somatostatin levels in the perfusates of streptozotocin-treated animals were not significantly different from those of the control animals. However, the peak values of somatostatin release induced by 5 x 10(-9) M glucagon in the diabetic animals were significantly higher than those of the controls. These results lead us to conclude that a hyperfunctioning state of the gastric D-Cells exists in hypoinsulinemic diabetes.Entities:
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Year: 1981 PMID： 6110599 DOI： 10.2337/diab.30.3.188
Source DB: PubMed Journal: Diabetes ISSN： 0012-1797 Impact factor: 9.461