Literature DB >> 6110554

Effects of sulphasalazine on prostaglandin inactivation and synthesis in isolated lungs of guinea pig, rat and man.

Y S Bakhle.   

Abstract

Sulphasalazine 10(-4M) inhibited PGE2 inactivation in isolated perfused lungs from guinea pig, rat and man and, in guinea pig and rat lungs, inhibited 16,16-dimethyl PGE2 inactivation and accelerated efflux of radioactivity following injection of [14C]PGE2. In rat and human, but not in guinea-pig lung, sulphasalazine inhibited activation of exogenous arachidonate to PG-like substances. Thus sulphasalazine inhibited PG inactivation by inhibiting PG uptake; there was a marked species difference in its effects on arachidonate activation.

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Year:  1980        PMID： 6110554     DOI： 10.1016/0014-2999(80)90425-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  Inhibitors of prostaglandin dehydrogenase (Ph CL 28A and Ph CK 61A) increase output of prostaglandins from rat isolated lung.

Authors:  Y S Bakhle; J J Pankhania
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

2.  Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Authors:  G de Nucci; R Thomas; P D'Orleans-Juste; E Antunes; C Walder; T D Warner; J R Vane
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

3.  Effect of sulphasalazine on pulmonary inactivation of prostaglandin F2 alpha in the pig.

Authors:  P G Hellewell; J D Pearson
Journal:  Br J Pharmacol       Date:  1982-06       Impact factor: 8.739
  3 in total

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