Literature DB >> 6110221

Sequential conversion of the glutathionyl side chain of slow reacting substance (SRS) to cysteinyl-glycine and cysteine in rat basophilic leukemia cells stimulated with A-23187.

C W Parker, S F Falkenhein, M M Huber.   

Abstract

In rat basophilic leukemia (RBL-1) cells stimulated with A-23187, the major slow reacting substance (SRS) species contain glutathione, cysteinyl-glycine, or cysteine in their side chains, corresponding or closely related to leukotrienes LTC4, LTD4, and LTE4, respectively. Evidence is presented that most of the SRS produced during the first few minutes of stimulation by the ionophore has a glutathionyl side chain which is sequentially converted to cysteinyl-glycine and cysteine.

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Year:  1980        PMID： 6110221     DOI： 10.1016/0090-6980(80)90139-2

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  11 in total

Review 1.  The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications.

Authors:  K Frank Austen; Akiko Maekawa; Yoshihide Kanaoka; Joshua A Boyce
Journal:  J Allergy Clin Immunol       Date:  2009-08-03       Impact factor: 10.793

2.  Characterization of phospholipase C from Pseudomonas aeruginosa as a potent inflammatory agent.

Authors:  D J Meyers; R S Berk
Journal:  Infect Immun       Date:  1990-03       Impact factor: 3.441

3.  The comparative effects of dietary alpha-linolenic acid and fish oil on 4- and 5-series leukotriene formation in vivo.

Authors:  J Whelan; K S Broughton; J E Kinsella
Journal:  Lipids       Date:  1991-02       Impact factor: 1.880

4.  Bioconversion of C-6 sulfidopeptide leukotrienes by the responding guinea pig ileum determines the time course of its contraction.

Authors:  S Krilis; R A Lewis; E J Corey; K F Austen
Journal:  J Clin Invest       Date:  1983-04       Impact factor: 14.808

Review 5.  Metabolism of leukotrienes.

Authors:  S Hammarström; L Orning; K Bernström
Journal:  Mol Cell Biochem       Date:  1985-11       Impact factor: 3.396

6.  Oxidative inactivation of leukotriene C4 by stimulated human polymorphonuclear leukocytes.

Authors:  C W Lee; R A Lewis; E J Corey; A Barton; H Oh; A I Tauber; K F Austen
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

7.  Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors.

Authors:  T H Lee; K F Austen; E J Corey; J M Drazen
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

8.  Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes.

Authors:  C W Lee; R A Lewis; E J Corey; K F Austen
Journal:  Immunology       Date:  1983-01       Impact factor: 7.397

9.  An in vivo model for measuring antigen-induced SRS-A-mediated bronchoconstriction and plasma SRS-A levels in the guinea-pig.

Authors:  W H Anderson; M O'Donnell; B A Simko; A F Welton
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

10.  Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation.

Authors:  Nora A Barrett; James M Fernandez; Akiko Maekawa; Wei Xing; Li Li; Matthew W Parsons; K Frank Austen; Yoshihide Kanaoka
Journal:  J Immunol       Date:  2012-09-21       Impact factor: 5.422
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