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Literature DB >> 6109412

[Investigations of clobazam (Frisium) by combined gas chromatography/mass spectrometry (author's transl)].

Abstract

Clobazam (Frisium) was hydrolyzed according to three methods commonly used in the determination of 1.4-benzo-diazepines; the reaction products were analyzed by gas chromatography/mass spectrometry and thin-layer chromatography. Five degradation products were obtained for which structure proposals are discussed. After oral intake two of these substances were also detected in human urine. It should be recognized that some of the above mentioned substances may be on-column degradation products of artifacts occurring during hydrolyzation and/or sample clean-up.

Entities: Chemical Species

Mesh：

Substances：

Year: 1980 PMID： 6109412 DOI： 10.1007/bf00201293

Source DB: PubMed Journal: Z Rechtsmed ISSN： 0044-3433

10 in total

1. Fluorometric determination of clobazam, a 1,5-benzodiazepine, in human plasma.

Authors: J T Stewart; I L Honigberg; A Y Tsai; P Hajdu
Journal: J Pharm Sci Date: 1979-04 Impact factor: 3.534

2. [Analytical data of the new 1,5-benzodiazepine clobazam (Frisium) and its main metabolite nor-clobazam (author's transl)].

Authors: H Schütz
Journal: Arch Toxicol Date: 1978-12-28 Impact factor: 5.153

9. Quantitative determination of clobazam in serum and urine by gas chromatography, thin layer chromatography and fluorometry.

Authors: P Hajdú; M Uihlein; D Damm
Journal: J Clin Chem Clin Biochem Date: 1980-04

10. [GLC-data of 19 hydrolysis-derivatives rised from 12 important benzodiazepines and 17 main-metabolites (author's transl)].

Authors: H Schütz; V Westenberger
Journal: Z Rechtsmed Date: 1978-09-28

10 in total

3 in total

1. [Contribution to biotransformation and analysis of the psychopharmacon mefexamide (author's transl)].

Authors: W Gielsdorf
Journal: Z Rechtsmed Date: 1981

2. [Analysis and renal excretion of pirisudanol (Stivane)].

Authors: W Gielsdorf; E Klug
Journal: Z Rechtsmed Date: 1983

3. [Quantitative determination of mefexamide and its main degradation product desmethyl-mefexamide in human urine after ingestion of therapeutic doses (author's transl)].

Authors: W Gielsdorf; M Herper
Journal: Z Rechtsmed Date: 1981

3 in total

[Investigations of clobazam (Frisium) by combined gas chromatography/mass spectrometry (author's transl)].

1. Fluorometric determination of clobazam, a 1,5-benzodiazepine, in human plasma.

2. [Analytical data of the new 1,5-benzodiazepine clobazam (Frisium) and its main metabolite nor-clobazam (author's transl)].

3. The gas chromatography mass spectrometry of the major metabolites of flurazepam.

4. Gas-liquid chromatographic determination of clobazam and n-desmethyl-clobazam in plasma.

5. [Determination of benzodiazepines in forensic chemistry].

Review 6. The determination of some 1,4-benzodiazepines and their metabolites in body fluids. A review.

Review 7. Chromatography of the 1,4-benzodiazepines.

8. [Detection of clobazam (Frisium) in biological material (author's transl)].

9. Quantitative determination of clobazam in serum and urine by gas chromatography, thin layer chromatography and fluorometry.

10. [GLC-data of 19 hydrolysis-derivatives rised from 12 important benzodiazepines and 17 main-metabolites (author's transl)].

1. [Contribution to biotransformation and analysis of the psychopharmacon mefexamide (author's transl)].

2. [Analysis and renal excretion of pirisudanol (Stivane)].

3. [Quantitative determination of mefexamide and its main degradation product desmethyl-mefexamide in human urine after ingestion of therapeutic doses (author's transl)].