Literature DB >> 6107906

Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.

A V Schally, W Y Huang, R C Chang, A Arimura, T W Redding, R P Millar, M W Hunkapiller, L E Hood.   

Abstract

An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys. This octacosapeptide possesses high somatotropin (growth hormone) and prolactin release-inhibiting activity in vitro. It also crossreacts strongly with antisera generated against the somatostatin tetradecapeptide. This octacosapeptide is most likely a precursor (pro-hormone) of somatostatin in the hypothalamus. The existence of still larger molecular size precursors of somatostatin was also observed.

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Year:  1980        PMID： 6107906      PMCID： PMC349869          DOI： 10.1073/pnas.77.8.4489

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Isolation and structure of somatostatin from porcine hypothalami.

Authors:  A V Schally; A Dupont; A Arimura; T W Redding; N Nishi; G L Linthicum; D H Schlesinger
Journal:  Biochemistry       Date:  1976-02-10       Impact factor: 3.162

Review 2.  Aspects of hypothalamic regulation of the pituitary gland.

Authors:  A V Schally
Journal:  Science       Date:  1978-10-06       Impact factor: 47.728

3.  Characterization of hypophysiotropic hormones in porcine hypothalamic extracts.

Authors:  A E Boyd; F Sanchez-Franco; E Spencer; Y C Patel; I M Jackson; S Reichlin
Journal:  Endocrinology       Date:  1978-10       Impact factor: 4.736

4.  Abnormal behaviour of proline in the isothiocyanate degradation.

Authors:  W F Brandt; P Edman; A Henschen; C Von Holt
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1976-11

5.  Immunological and biochemical characterization of distinct high molecular weight forms of neurophysin and somatostatin in mouse hypothalamus extracts.

Authors:  M Lauber; M Camier; P Cohen
Journal:  FEBS Lett       Date:  1979-01-15       Impact factor: 4.124

6.  N-terminally extended somatostatin: the primary structure of somatostatin-28.

Authors:  L Pradayrol; H Jörnvall; V Mutt; A Ribet
Journal:  FEBS Lett       Date:  1980-01-01       Impact factor: 4.124

7.  Direct microsequence analysis of polypeptides using an improved sequenator, a nonprotein carrier (polybrene), and high pressure liquid chromatography.

Authors:  M W Hunkapiller; L E Hood
Journal:  Biochemistry       Date:  1978-05-30       Impact factor: 3.162

8.  Analysis of phenylthiohydantoin amino acids by high-performance liquid chromatography on DuPont Zobax cyanopropylsilane columns.

Authors:  N D Johnson; M W Hunkapiller; L E Hood
Journal:  Anal Biochem       Date:  1979-12       Impact factor: 3.365

9.  Pancreatic somatostatinoma. Clinical features and physiological implications.

Authors:  L I Larsson; M A Hirsch; J J Holst; S Ingemansson; C Kühl; S L Jensen; G Lundqvist; J F Rehfeld; T W Schwartz
Journal:  Lancet       Date:  1977-03-26       Impact factor: 79.321
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  28 in total

1.  Interrelationships between somatostatin sst2A receptors and somatostatin-containing axons in rat brain: evidence for regulation of cell surface receptors by endogenous somatostatin.

Authors:  P Dournaud; H Boudin; A Schonbrunn; G S Tannenbaum; A Beaudet
Journal:  J Neurosci       Date:  1998-02-01       Impact factor: 6.167

2.  Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem.

Authors:  P K Lund; R H Goodman; P C Dee; J F Habener
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

3.  Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.

Authors:  L Yang; S C Berk; S P Rohrer; R T Mosley; L Guo; D J Underwood; B H Arison; E T Birzin; E C Hayes; S W Mitra; R M Parmar; K Cheng; T J Wu; B S Butler; F Foor; A Pasternak; Y Pan; M Silva; R M Freidinger; R G Smith; K Chapman; J M Schaeffer; A A Patchett
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

4.  Neuropeptide Y: complete amino acid sequence of the brain peptide.

Authors:  K Tatemoto
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

5.  Human somatostatin I: sequence of the cDNA.

Authors:  L P Shen; R L Pictet; W J Rutter
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

6.  Sequence of a cDNA encoding pancreatic preprosomatostatin-22.

Authors:  M Magazin; C D Minth; C L Funckes; R Deschenes; M A Tavianini; J E Dixon
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

7.  Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.

Authors:  R Benoit; P Böhlen; N Ling; A Briskin; F Esch; P Brazeau; S Y Ying; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

8.  Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin.

Authors:  S J Konturek; J Tasler; J Jaworek; W Pawlik; K M Walus; V Schusdziarra; C A Meyers; D H Coy; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

9.  High molecular weight peptide with corticotropin-releasing factor activity from porcine hypothalami.

Authors:  A V Schally; R C Chang; A Arimura; T W Redding; J B Fishback; S Vigh
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205

10.  Enzymes processing somatostatin precursors: an Arg-Lys esteropeptidase from the rat brain cortex converting somatostatin-28 into somatostatin-14.

Authors:  P Gluschankof; A Morel; S Gomez; P Nicolas; C Fahy; P Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205
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