Literature DB >> 6107726

Acute liver disease associated with sodium valproate.

S Ware, G H Millward-Sadler.   

Abstract

Five patients, four of them children, had acute liver disease after treatment with sodium valproate. Three died. The liver disease began 3-6 months after the start of treatment and was often associated with other side-effects of sodium valproate such as thrombocytopenia and hair loss.

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Year:  1980        PMID: 6107726     DOI: 10.1016/s0140-6736(80)92543-x

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  9 in total

1.  Hyperammonaemia and hepatotoxicity during chronic valproate therapy: enhancement by combination with other antiepileptic drugs.

Authors:  R N Ratnaike; G J Schapel; G Purdie; R H Rischbieth; S Hoffmann
Journal:  Br J Clin Pharmacol       Date:  1986-07       Impact factor: 4.335

2.  Carbamoylphosphate synthetase deficiency in an adult: deterioration due to administration of valproic acid.

Authors:  M Horiuchi; Y Imamura; N Nakamura; I Maruyama; T Saheki
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982

3.  Decreased serum carnitine in valproate induced Reye syndrome.

Authors:  H Böhles; K Richter; E Wagner-Thiessen; H Schäfer
Journal:  Eur J Pediatr       Date:  1982-11       Impact factor: 3.183

Review 4.  Hepatotoxicity to sodium valproate: a review.

Authors:  P R Powell-Jackson; J M Tredger; R Williams
Journal:  Gut       Date:  1984-06       Impact factor: 23.059

5.  Hyperaminoacidemia in epileptic children treated with valproic acid.

Authors:  M Castro-Gago; E Rodrigo-Saez; I Novo-Rodriguez; M F Camiña; S Rodriguez-Segade
Journal:  Childs Nerv Syst       Date:  1990-12       Impact factor: 1.475

6.  Effects of sodium valproate in 100 children with special reference to weight.

Authors:  J Egger; E M Brett
Journal:  Br Med J (Clin Res Ed)       Date:  1981-08-29

7.  Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid.

Authors:  K Iinuma; K Hayasaka; K Narisawa; K Tada; K Hori
Journal:  Eur J Pediatr       Date:  1988-12       Impact factor: 3.183

Review 8.  Clinical pharmacokinetics of valproic acid--1988.

Authors:  G Zaccara; A Messori; F Moroni
Journal:  Clin Pharmacokinet       Date:  1988-12       Impact factor: 6.447

9.  A comparison of phenytoin and valproate in previously untreated adult epileptic patients.

Authors:  D M Turnbull; M D Rawlins; D Weightman; D W Chadwick
Journal:  J Neurol Neurosurg Psychiatry       Date:  1982-01       Impact factor: 10.154

  9 in total

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