Pharmacopsychological investigation of changes in mood induced by dipotassium chlorazepate with and without simultaneous alcohol administration.

The effects on subjective well-being of a single oral dose of 20 mg dipotassium chlorazepate (DPC) with and without concurrent alcohol administration (1 g/kg) were tested on 14 male students. A reciprocal effect on the pharmacokinetics was not detected. The personal feeling scale and the semantic differential revealed an emotional damping 90 minutes after oral administration of DPC in the evening test. Under concurrent alcohol administration the alcohol-typical euphoric effect was increased by DPC and the dysphoric symptoms were reduced the following morning.