Literature DB >> 6107265

Comparative study with ranitidine and cimetidine on gastric secretion in normal volunteers.

K F Sewing, A Billian, H Malchow.   

Abstract

The inhibitory effect of ranitidine and cimetidine on pentagastrin stimulated volume, acid and pepsin secretion has been studied in eight healthy volunteers. Both compounds inhibit all measured components of gastric secretion in a dose dependent manner. On a molar basis ranitidine is on average 11.14 times for volume, 13.04 times for acid, and 9.74 times for pepsin secretion more potent than cimetidine as measured by the ID50-values.

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Year:  1980        PMID： 6107265      PMCID： PMC1419537          DOI： 10.1136/gut.21.9.750

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  3 in total

1.  A modified hemoglobin substrate method for the estimation of pepsin in gastric juice.

Authors:  A Berstad
Journal:  Scand J Gastroenterol       Date:  1970       Impact factor: 2.423

2.  Gastric inhibitory action of H2-antagonists ranitidine and cimetidine.

Authors:  W Domschke; G Lux; S Domschke
Journal:  Lancet       Date:  1979-02-10       Impact factor: 79.321

3.  Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. A new H2-receptor antagonist.

Authors:  N R Peden; J H Saunders; K G Wormsley
Journal:  Lancet       Date:  1979-03-31       Impact factor: 79.321
  3 in total
  9 in total

1.  Fundic accommodation assessed by SPECT scanning: comparison with the gastric barostat.

Authors:  B D J van den Elzen; R J Bennink; R E Wieringa; G N J Tytgat; G E E Boeckxstaens
Journal:  Gut       Date:  2003-11       Impact factor: 23.059

2.  Drug interactions through binding to cytochrome p 450: the experience with h2-receptor blocking agents.

Authors:  U Klotz; I W Reimann
Journal:  Pharm Res       Date:  1984-03       Impact factor: 4.200

3.  Gastro-oesophageal function in normal subjects after oral administration of ranitidine.

Authors:  L Wallin; T Madsen; S Boesby
Journal:  Gut       Date:  1983-02       Impact factor: 23.059

4.  Prevention of taurocholate-induced drop in gastric potential difference with ranitidine in man.

Authors:  P Müller; H Kather; B Simon; H G Dammann
Journal:  Dig Dis Sci       Date:  1982-08       Impact factor: 3.199

5.  Effect of cimetidine on gastric secretion and duodenogastric reflux.

Authors:  R J Melville; S I Suleiman; P F Whitfield; J V Parkin; T O Nwabunike; M Hobsley
Journal:  Gut       Date:  1985-08       Impact factor: 23.059

6.  Ranitidine upon meal-induced gastric secretion: oral pharmacokinetics and plasma concentration effect relationships.

Authors:  M Mignon; N P Chau; B K Nguyen-Phuoc; M Sauvage; F Leguy; S Bonfils
Journal:  Br J Clin Pharmacol       Date:  1982-08       Impact factor: 4.335

Review 7.  Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases.

Authors:  R N Brogden; A A Carmine; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-10       Impact factor: 9.546

8.  Complete inhibition of food-stimulated gastric acid secretion by combined application of pirenzepine and ranitidine.

Authors:  W Londong; V Londong; C Ruthe; P Weizert
Journal:  Gut       Date:  1981-07       Impact factor: 23.059

9.  Influence of gastric pH modifiers on development of intestinal metaplasia induced by X-irradiation in rats.

Authors:  H Watanabe; T Okamoto; Y Fudaba; P O Ogundigie; A Ito
Journal:  Jpn J Cancer Res       Date:  1993-10
  9 in total

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