Literature DB >> 6107246

Isolation and characterization of rat pancreatic somatostatin.

R Benoit, P Böhlen, P Brazeau, N Ling, R Guillemin.   

Abstract

A peptide representing the major form of somatostatin-like immunoreactivity was isolated from 600 rat pancreata by using anti-somatostatin affinity chromatography, gel permeation chromatography and reverse-phase high-performance liquid chromatography (HPLC). The isolated peptide elutes with the same retention time as synthetic somatostatin-14 in isocratic HPLC and its amino acid composition is in agreement with that of the tetradecapeptide. We propose that the structure of the major rat pancreatic somatostatin is identical to that of somatostatin-14 characterized in other species.

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Year:  1980        PMID： 6107246     DOI： 10.1210/endo-107-6-2127

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  13 in total

1.  Hypothalamic somatostatin may mediate endotoxin-induced fever in the rat.

Authors:  M T Lin; W N Uang; L T Ho
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-06       Impact factor: 3.000

2.  Effect of somatostatin on amylase secretion from in vivo and in vitro rat pancreas.

Authors:  M Singh
Journal:  Dig Dis Sci       Date:  1986-05       Impact factor: 3.199

3.  Structure-activity relationships of somatostatin analogs in the rabbit ileum and the rat colon.

Authors:  L E Rosenthal; D J Yamashiro; J Rivier; W Vale; M Brown; K Dharmsathaphorn
Journal:  J Clin Invest       Date:  1983-04       Impact factor: 14.808

Review 4.  Somatostatin.

Authors:  S R Bloom; J M Polak
Journal:  Br Med J (Clin Res Ed)       Date:  1987-08-01

5.  The hypothalamic somatostatinergic pathways mediate feeding behavior in the rat.

Authors:  L T Ho; Y F Chern; M T Lin
Journal:  Experientia       Date:  1989-02-15

Review 6.  Paracrine signaling in islet function and survival.

Authors:  Sean M Hartig; Aaron R Cox
Journal:  J Mol Med (Berl)       Date:  2020-02-17       Impact factor: 4.599

7.  Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.

Authors:  R Benoit; P Böhlen; N Ling; A Briskin; F Esch; P Brazeau; S Y Ying; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

8.  Immunocytochemical localization of prosomatostatin fragments in maturing and mature secretory granules of pancreatic and gastrointestinal D cells.

Authors:  M Ravazzola; R Benoit; N Ling; R Guillemin; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

9.  Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiography.

Authors:  M Amherdt; Y C Patel; L Orci
Journal:  J Clin Invest       Date:  1987-11       Impact factor: 14.808

10.  Somatostatin inhibits vasopressin-stimulated phosphoinositide hydrolysis and influx of extracellular calcium in clonal hamster beta (HIT) cells.

Authors:  S B Richardson; T Laya; M Gibson; N Eyler; M Van Ooy
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857
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