[On the manufacture and testing of butaperazine matrix tablets with silicone varnish NH 30 as a structural substance (author's transl)].

It is reported of the manufacture and testing of matrix tablets containing butaperazine dihydrogen maleinate as a model substance and silicone varnish NH 30 as a structural constituent. On in vitro testing in artificial gstric juice (pH = 1.2), The drug was fully available when the tablets had been prepared by the method of separate granulation. Furthermore, the release of the drug was studied by means of the half-change method at different pH values, in artificial intestinal juice (pH = 7.5) and under sink conditions. The last-mentioned method is concerned with the drug transferred in vitro. Variations in pressing pressure and varnish concentration permit to prepare tablets of planned release characteristics. The release rates were higher in systems with n-heptane as the lipophil phase than in systems under non-sink conditions. This method is sensitive enough to differentiate among batches of tablets varying in drug release.