Literature DB >> 6106018

Inhibition of leukotriene C and leukotriene D biosynthesis.

L Orning, S Hammarström.   

Abstract

Leukotriene C4 and leukotriene D4 are slow reacting substances produced by mouse mastocytoma cells and rat basophilic leukemia cells, respectively. Serine x borate complex, an inhibitor of glutamyl transpeptidase (EC 2.3.2.2), prevented the formation of the biologically more potent leukotriene D4 and caused accumulation of leukotriene C4 in rat basophilic leukemia cell suspensions. 5,8,11-Eicosatriynoic acid, a lipoxygenase inhibitor, prevented the biosynthesis of leukotriene C4 (ID50, 5 microM) by mastocytoma cells. The results demonstrate that gamma-glutamyl transpeptidase is involved in the biosynthesis of leukotriene D4 and suggest that leukotriene C4 is formed as an intermediate.

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Year:  1980        PMID： 6106018

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  32 in total

1.  Leukotrienes in teleost fish gills.

Authors:  D Piomelli
Journal:  Naturwissenschaften       Date:  1985-05

2.  Slow reacting substances (leukotrienes): enzymes involved in their biosynthesis.

Authors:  H R Morris; G W Taylor; C M Jones; P J Piper; M N Samhoun; J R Tippins
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

3.  Generation of leukotriene C4 from a subclass of mast cells differentiated in vitro from mouse bone marrow.

Authors:  E Razin; J M Mencia-Huerta; R A Lewis; E J Corey; K F Austen
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

4.  Depletion of glutathione selectively inhibits synthesis of leukotriene C by macrophages.

Authors:  C A Rouzer; W A Scott; O W Griffith; A L Hamill; Z A Cohn
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

5.  Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion.

Authors:  R L Hoover; M J Karnovsky; K F Austen; E J Corey; R A Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

6.  Role of lipoxygenase products in murine pulmonary granuloma formation.

Authors:  S L Kunkel; S W Chensue; C Mouton; G I Higashi
Journal:  J Clin Invest       Date:  1984-08       Impact factor: 14.808

Review 7.  Leukotrienes in pulmonary arterial hypertension.

Authors:  Wen Tian; Xinguo Jiang; Yon K Sung; Jin Qian; Ke Yuan; Mark R Nicolls
Journal:  Immunol Res       Date:  2014-05       Impact factor: 2.829

8.  Stimulation of arachidonic acid metabolism and generation of thromboxane A2 by leukotrienes B4, C4 and D4 in guinea-pig lung in vitro.

Authors:  P J Piper; M N Samhoun
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

9.  Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes.

Authors:  C W Lee; R A Lewis; E J Corey; K F Austen
Journal:  Immunology       Date:  1983-01       Impact factor: 7.397

10.  Activation of human basophils by staphylococcal protein A. I. The role of cyclic AMP, arachidonic acid metabolites, microtubules and microfilaments.

Authors:  G Marone; S Poto; R Petracca; M Triggiani; E de Lutio di Castelguidone; M Condorelli
Journal:  Clin Exp Immunol       Date:  1982-12       Impact factor: 4.330
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