| Literature DB >> 6105393 |
Abstract
Two patients with cutaneous metastatic melanoma were treated with a topical retinoid, beta-all-trans-retinoic acid. Complete regression of the treated lesions was noted in one patient and a partial response was seen in the other patient. The mechanism of anti-tumour action of the retinoids is not completely known but binding to intracytoplasmic receptors with promotion of cellular differentiation, alteration of membranes, and immunological adjuvant effects may be involved.Entities:
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Year: 1980 PMID： 6105393 DOI： 10.1016/s0140-6736(80)90119-1
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321