| Literature DB >> 6105339 |
H G Prentice, J F Smyth, K Ganeshaguru, B Wonke, K F Bradstock, G Janossy, A H Goldstone, A V Hoffbrand.
Abstract
Two patients with relapsed acute lymphoblastic leukaemia of thymic phenotype (Thy-ALL) resistant to all conventional chemotherapy achieved complete remission when treated with 2'-deoxycoformycin, a selectively lymphocytotoxic compound that acts by inhibition of the enzyme adenosine deaminase. These observations show that malignant thymocytes are dependent on adenosine-deaminase activity and suggest that it may be possible to use deoxycoformycin in other patients with Thy-ALL to induce remission or to kill Thy-ALL blasts in bone marrow harvested before autologous bone-marrow transplantation, leaving normal haemopoietic stem cells intact.Entities:
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Year: 1980 PMID： 6105339 DOI： 10.1016/s0140-6736(80)90060-4
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321