Literature DB >> 6105091

Autoradiographic evidence for binding of 3H-flunitrazepam (Rohypnol) to melanin granules in the cat eye.

H Kuhn.   

Abstract

This autoradiographic study revealed after an i.,v. injection an accumulation of 3H-flunitrazepam in melanin granules of the pigment epithelium and of the choroid cells. It seems that after a short period, a large proportion of the strongly bound drug is released.

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Year:  1980        PMID： 6105091     DOI： 10.1007/bf01978617

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Chloroquine retinopathy in the rat.

Authors:  S W Thompson
Journal:  Vet Pathol       Date:  1975       Impact factor: 2.221

2.  THE REACTION OF UVEAL PIGMENT IN VITRO WITH POLYCYCLIC COMPOUNDS.

Authors:  A M POTTS
Journal:  Invest Ophthalmol       Date:  1964-08

3.  The concentration of phenothiazines in the eye of experimental animals.

Authors:  A M POTTS
Journal:  Invest Ophthalmol       Date:  1962-08

4.  Study of chloroquine toxicity and a drug-induced cerebrospinal lipodystrophy in swine.

Authors:  C A Gleiser; W W Bay; T W Dukes; R S Brown; W K Read; K R Pierce
Journal:  Am J Pathol       Date:  1968-07       Impact factor: 4.307

5.  Irreversible lysosomal damage induced by chloroquine in the retinae of pigmented and albino rats.

Authors:  R Abraham; R J Hendy
Journal:  Exp Mol Pathol       Date:  1970-04       Impact factor: 3.362

6.  Differences in the retinotoxic action of chloroquine and phenothiazine derivatives.

Authors:  M H Gregory; D A Rutty; R D Wood
Journal:  J Pathol       Date:  1970-11       Impact factor: 7.996

7.  The affinity of melanin for chloroquine.

Authors:  W M Sams; J H Epstein
Journal:  J Invest Dermatol       Date:  1965-12       Impact factor: 8.551
  7 in total
  4 in total

1.  Incorporation of 3H-befunolol (beta-blocking agent) into melanin granules of ocular tissues in the pigmented rabbits. I. Light microscopic radioautography.

Authors:  S Yamabayashi; W Gunarso; S Tsukahara; T Nagata
Journal:  Histochemistry       Date:  1981-12

2.  Lack of correlation between melanin affinity and retinopathy in mice and cats treated with chloroquine or flunitrazepam.

Authors:  H Kuhn; P Keller; E Kovács; A Steiger
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1981

3.  Disposition of premazepam, an anti-anxiety pyrrolodiazepine, in the cynomolgus monkey.

Authors:  G Zanolo; M C Giachetti; S Canali; A Bernareggi; G Tarzia; A Assandri
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Apr-Jun       Impact factor: 2.441

4.  Structural alterations of tapetal cells in the retina of cats induced by prolonged treatment with chloroquine.

Authors:  H Kuhn; A Steiger
Journal:  Cell Tissue Res       Date:  1981       Impact factor: 5.249
  4 in total

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