Literature DB >> 6105073

Evaluation of serum guanase in hepatic diseases.

R Kuzmits, H Seyfried, A Wolf, M M Müller.   

Abstract

Serum guanase activity was measured in 20 healthy adults and in 62 patients with acute viral hepatitis, chronic active hepatitis, chronic persistent hepatitis, liver cirrhosis and fatty liver. Guanase and gamma-GT in patients were elevated in 87 and 64%, respectively. Elevated guanase activities were found in most cases of acute viral hepatitis, as well as in chronic hepatopathies. In patients with acute viral hepatitis pathologic activities of guanase were found following partial or total normalization of other liver function tests.

Entities:  

Mesh:

Substances:

Year:  1980        PMID: 6105073     DOI: 10.1159/000459240

Source DB:  PubMed          Journal:  Enzyme        ISSN: 0013-9432


  4 in total

1.  Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin, a minor red eye pigment of Drosophila.

Authors:  Jaekwang Kim; Sang Ick Park; Chiyoung Ahn; Heuijong Kim; Jeongbin Yim
Journal:  J Biol Chem       Date:  2009-06-30       Impact factor: 5.157

2.  Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine.

Authors:  José R Fernández; Eric S Sweet; William J Welsh; Bonnie L Firestein
Journal:  Bioorg Med Chem       Date:  2010-07-27       Impact factor: 3.641

3.  Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines.

Authors:  Saritha Tantravedi; Saibal Chakraborty; Niti H Shah; James C Fishbein; Ramachandra S Hosmane
Journal:  Bioorg Med Chem       Date:  2013-07-11       Impact factor: 3.641

4.  Characterization of Xenopus laevis guanine deaminase reveals new insights for its expression and function in the embryonic kidney.

Authors:  Paula G Slater; Garrett M Cammarata; Connor Monahan; Jackson T Bowers; Oliver Yan; Sangmook Lee; Laura Anne Lowery
Journal:  Dev Dyn       Date:  2019-02-19       Impact factor: 3.780

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.