[Clinical study on stress protective action of cloxazolam in jaw surgery in double blind comparison to placebo (author's transl)].

An investigation in 50 patients has shown that biochemical measurements of dopamine-beta-hydroxylase (DBH), ACTH and cortisol as well as the concentration of glucose and insulin signal a reduction of surgical stress under the medication of the tranquilizer 10-chloro-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo[6,7]-1,4-diazepino[5,4-b]oxazol-6-one (cloxazolam, MT 14-411). There was an inhibition of the DBH-increase during the surgical procedure and an inhibition of the ACTH- and cortisol-secretion before and during surgery as well as a reduction of the insulin antagonizing effect during sympathicoadrenal stimulation. With the exception of a sedative action no other side effects have been observed.

RCT Entities:   Population Interventions Outcomes