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Literature DB >> 6104653

Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP).

Abstract

Cytochemical methods were used to demonstrate the inhibitory effect of salicylazosulfapyridine (SASP) on the activity of neutral proteases produced by neutrophilic granulocytes (PMN proteases). The SASP metabolites (5-aminosalicylic acid and sulfapyridine), produced by splitting of SASP by bacteria in the colon, did not inhibit the activity of PMN proteases. Paradoxically, sulfapyridine intensified PMN protease activity. A similar effect however could not be demonstrated for 5-aminosalicylic acid.

Entities: Chemical

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Year: 1980 PMID： 6104653 DOI： 10.1007/bf00493244

Source DB: PubMed Journal: Histochemistry ISSN： 0301-5564

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References

7 in total

Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP).

1. Distribution and metabolism of salicyl-azo-sulfapyridine. I. A study with C-14-5-amino-salicylic acid.

2. [Simplification of the reaction after Hale (1946)].

3. On testing the activity of proteases from human polymorphonuclear neutrophils on blood smears.

4. The role of intestinal bacteria in the metabolism of salicylazosulfapyridine.

5. Absorption, metabolism, and excretion of salicylazosulfapyridine in man.

6. Treatment of ulcerative colitis with salazopyrin.

7. An experiment to determine the active therapeutic moiety of sulphasalazine.