Prediction of axillary metastases in breast cancer by lymphoscintigraphy.

A new technique of axillary lymphoscintigraphy has been investigated in thirty patients with breast carcinoma. Intradermal injection of 100 muCi technetium-99m antimony sulphide colloid in 0.1 ml buffer produced satisfactory scans of axillary lymph-nodes in twenty-seven patients (90%). Ten patients with node metastases from breast cancer (9 confirmed histologically) had a defect in the lower axillary uptake on the side of the lesion. Three of the remaining seventeen patients with breast cancer and normal scans had nodal metastases seen histologically, but in two these were micro-metastases only. Axillary lymphoscintigraphy improved considerably the clinical assessment of node status, and corrected the clinical classification in five of six patients who had been misclassified by clinical examination.