2,4-Dihydro-6-phenyl-1H-s-triazolo[4,3-a][1,4]benzoidiazepin-1-ones with antianxiety and antidepressant activity.

A series of 2,4-dihydro-6-phenyl-1H-s-triazolo[4,3-a][1,4]benzodiazepin-1-ones was prepared and evaluated for central nervous system activity. It was found that the 2-methyl-substituted analogues had interesting activity in tests useful for detecting anxiolytic agents, while N-2 substitution with omega-(dialkylamino)alkyl substituents give compounds with antidepressant potential as well as antianxiety activity.