Literature DB >> 6103880

Effect of alphamethyldopa on the half-lives of antipyrine, tolbutamide and D-glucaric acid excretion in man.

B Gachályi, M Tornyossy, A Vas, A Káldor.   

Abstract

Alphamethyldopa has been found to prolong the biological half-lives of Antipyrine and Tolbutamide and to decrease D-glucaric acid excretion in man. These observations suggest that the liver microsomal enzyme system metabolizing drug in man is inhibited by alphamethyldopa. No side effects were found during treatment with alphamethyldopa at the dose levels used in this study.

Entities:  

Mesh:

Substances:

Year:  1980        PMID: 6103880

Source DB:  PubMed          Journal:  Int J Clin Pharmacol Ther Toxicol        ISSN: 0174-4879


  3 in total

Review 1.  Clinical pharmacology of sulphonylurea hypoglycaemic agents: part 2.

Authors:  J E Jackson; R Bressler
Journal:  Drugs       Date:  1981-10       Impact factor: 9.546

2.  Clonidine effects on disposition of xenobiotics in rats: inhibited elimination of flow-limited but not extraction-limited agents.

Authors:  Z Ben-Zvi; A Hurwitz
Journal:  Br J Pharmacol       Date:  1988-05       Impact factor: 8.739

Review 3.  Pharmacokinetic-pharmacodynamic relationships of oral hypoglycaemic agents. An update.

Authors:  P Marchetti; R Navalesi
Journal:  Clin Pharmacokinet       Date:  1989-02       Impact factor: 6.447

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.