Literature DB >> 6103810

In vitro modulation by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranes.

P Placheta, M Karobath.   

Abstract

SQ 20009 and SQ 65396, two new pyrazolopyridines with anxiolytic properties in animals, reversibly increased Na+-independent 3H-GABA binding to rat cerabral cortex membranes in vitro. This modulation was partially chloride dependent and sensitive to Triton-X 100. Kinetic analysis of 3H-muscimol binding revealed an increase of the apparent number of binding sites. The results are compatible with a functional association between Na+-independent GABA binding sites and the GABA/benzodiazepine receptor complex.

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Year:  1980        PMID： 6103810     DOI： 10.1016/0014-2999(80)90281-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research.

Authors:  R F Squires; E Saederup
Journal:  Neurochem Res       Date:  2000-12       Impact factor: 3.996

2.  Interactions of some anaesthetic, convulsant, and anticonvulsant drugs at GABA-benzodiazepine receptor-ionophore complexes in rat brain synaptosomal membranes.

Authors:  J H Skerritt; G A Johnston
Journal:  Neurochem Res       Date:  1983-10       Impact factor: 3.996

3.  The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Enhancement of gamma-aminobutyrate-receptor binding by the anaesthetic propanidid.

Authors:  E F Kirkness; A J Turner
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857

4.  Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells.

Authors:  C R Snell; P H Snell
Journal:  Br J Pharmacol       Date:  1984-11       Impact factor: 8.739

5.  Kinetic properties of the pentobarbitone-gated chloride current in frog sensory neurones.

Authors:  N Akaike; T Maruyama; N Tokutomi
Journal:  J Physiol       Date:  1987-12       Impact factor: 5.182

Review 6.  GABA agonists. Development and interactions with the GABA receptor complex.

Authors:  P Krogsgaard-Larsen; E Falch
Journal:  Mol Cell Biochem       Date:  1981-08-11       Impact factor: 3.396

Review 7.  The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.

Authors:  R W Olsen
Journal:  Mol Cell Biochem       Date:  1981-09-25       Impact factor: 3.396

8.  Binding of 3H-DMCM to benzodiazepine receptors; chloride dependent allosteric regulation mechanisms.

Authors:  T Honoré; M Nielsen; C Braestrup
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

9.  Non-competitive inhibition of GABAA responses by a new class of quinolones and non-steroidal anti-inflammatories in dissociated frog sensory neurones.

Authors:  T Yakushiji; T Shirasaki; N Akaike
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

10.  Barbiturate receptor sites are coupled to benzodiazepine receptors.

Authors:  F Leeb-Lundberg; A Snowman; R W Olsen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205
  10 in total

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