Literature DB >> 6103159

Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glucosylated proteins.

B A McVerry, C Fisher, A Hopp, E R Huehns.   

Abstract

Plasma proteins glucosylated in vitro were injected repeatedly into 7 mice. A group of 4 was given multiple injections of non-glucosylated plasma proteins and another 10 were untreated. 5 of 7 mice given glucosylated proteins had glomerular-basement-membrane thickening on electron microscopical examination. This feature is characteristic of human and experimental diabetic renal disease. These results suggest that there may be a link between plasma-protein glucosylation and diabetic nephropathy.

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Year:  1980        PMID： 6103159     DOI： 10.1016/s0140-6736(80)91234-9

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  18 in total

1.  Detection of the terminal fluid-phase complement complex, SC5b-9, in the plasma of patients with insulin-dependent (type I) diabetes mellitus. Relation to increased urinary albumin excretion and plasma von Willebrand factor.

Authors:  G Triolo; E Giardina; D Casiglia; G Scarantino; G D Bompiani
Journal:  Clin Exp Immunol       Date:  1991-04       Impact factor: 4.330

2.  Prevention of decline in renal function in the diabetic db/db mouse.

Authors:  M P Cohen; R S Clements; J A Cohen; C W Shearman
Journal:  Diabetologia       Date:  1996-03       Impact factor: 10.122

Review 3.  Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases.

Authors:  José D Méndez; Jianling Xie; Montserrat Aguilar-Hernández; Verna Méndez-Valenzuela
Journal:  Mol Cell Biochem       Date:  2010-07-31       Impact factor: 3.396

4.  Effects of glycated albumin on mesangial cells: evidence for a role in diabetic nephropathy.

Authors:  F N Ziyadeh; M P Cohen
Journal:  Mol Cell Biochem       Date:  1993-08-11       Impact factor: 3.396

Review 5.  Combating diabetic nephropathy with drug therapy.

Authors:  D Martins; K Norris
Journal:  Curr Diab Rep       Date:  2001-10       Impact factor: 4.810

6.  Non-enzymatic glycosylation of urinary proteins in type 1 (insulin-dependent) diabetes: correlation with metabolic control and the degree of proteinuria.

Authors:  G Gragnoli; A M Signorini; I Tanganelli
Journal:  Diabetologia       Date:  1984-06       Impact factor: 10.122

7.  Poor metabolic control, hypertension and microangiopathy independently increase the transcapillary escape rate of albumin in diabetes.

Authors:  J A O'Hare; J B Ferriss; B Twomey; D J O'Sullivan
Journal:  Diabetologia       Date:  1983-09       Impact factor: 10.122

8.  Non-enzymatically glycosylated serum protein in diabetes mellitus: an index of short-term glycaemia.

Authors:  L Kennedy; T D Mehl; W J Riley; T J Merimee
Journal:  Diabetologia       Date:  1981-08       Impact factor: 10.122

9.  Retrospective glycemic status of diabetic patients: glycosylation of blood proteins in diabetes and chronic renal failure.

Authors:  K Kumari; V Bansal; C G Agarwal; A K Rastogi; M K Sahib
Journal:  Acta Diabetol Lat       Date:  1987 Apr-Jun

10.  Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy.

Authors:  R Zatz; T W Meyer; H G Rennke; B M Brenner
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205
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