Inhibition of Rous sarcoma-virus-induced transformation by proteins involved in blood coagulation.

Plasma, serum and the main proteins involved in the final steps of blood coagulation, fibrinogen, thrombin and plasma transglutaminase, have been tested for their ability to inhibit cell transformation and/or to induce reversion of the transformed to the normal phenotype in RSV-infected chicken embryo fibroblasts. The results obtained show that plasma, and not serum, fibrinogen, when converted to fibrin by thrombin, and activated transglutaminase alone prevent focus appearance and cause reversion of transformed to normal cell morphology.