| Literature DB >> 6102608 |
J R Pfister, W E Wymann, M E Schuler, A P Roszkowski.
Abstract
Twenty-five flavone-6-carboxylic acids were synthesized and tested as to their ability to inhibit histamine-induced gastric acid secretion in the rat. 3-Isopropoxy-4'-methoxyflavone-6-carboxylic acid (41) showed consistent oral activity while being devoid of any other noteworthy pharmacological effects. In vitro, this compound was found to be inactive as a histamine H2 antagonist, and its mode of action remains unknown.Entities:
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Year: 1980 PMID： 6102608 DOI： 10.1021/jm00177a029
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446