Literature DB >> 6102405

The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).

L Allen, R Meck, A Yunis.   

Abstract

AT-125, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 microM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 gamma-glutamyl transpeptidase (10 nmol/min/10(6) cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 microM.

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Year:  1980        PMID： 6102405

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  18 in total

Review 1.  Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.

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Review 2.  gamma-Glutamyl transpeptidase: catalytic, structural and functional aspects.

Authors:  S S Tate; A Meister
Journal:  Mol Cell Biochem       Date:  1981-09-25       Impact factor: 3.396

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4.  Glutathione and glutathione conjugate efflux from cultured liver cells.

Authors:  M J Meredith
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5.  Studies of the mechanism of nephrotoxicity of compound A in rats.

Authors:  J L Martin; L Kandel; M J Laster; R L Kerschmann; E I Eger
Journal:  J Anesth       Date:  1997-03       Impact factor: 2.078

6.  gamma-Glutamyl transpeptidase expression in Ewing's sarcoma cells: up-regulation by interferons.

Authors:  Lena Bouman; Josiane Sancéau; Dany Rouillard; Brigitte Bauvois
Journal:  Biochem J       Date:  2002-06-15       Impact factor: 3.857

7.  Enhancement of pulmonary metastasis formation and gamma-glutamyltranspeptidase activity in B16 melanoma induced by differentiation in vitro.

Authors:  J A Prezioso; N Wang; L Duty; W D Bloomer; E Gorelik
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8.  Sensitivity of cultured pancreatic carcinoma cells to Acinetobacter glutaminase-asparaginase.

Authors:  M C Wu; G K Arimura; J S Holcenberg; A A Yunis
Journal:  In Vitro       Date:  1982-09

9.  Radioprotection of human lymphoid cells by exogenously supplied glutathione is mediated by gamma-glutamyl transpeptidase.

Authors:  G L Jensen; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

10.  Glutathione is required for intestinal function.

Authors:  J Mårtensson; A Jain; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205
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