Literature DB >> 6102347

Disarming the box-jellyfish: nematocyst inhibition in Chironex fleckeri.

R Hartwick, V Callanan, J Williamson.   

Abstract

Laboratory tests indicate that methylated spirits, widely espoused as a first-aid treatment for jellyfish stings, causes massive discharge of nematocysts in living tentacles of the box-jellyfish, Chironex fleckeri. This action, together with demonstrated hazards of flammability and intoxication, casts doubt on this substance as a treatment for Chironex stings. In an attempt to find a substitute which will be effective in inactivating unfired nematocysts in the tentacles adhering to sting victims, a number of substances were tested in the laboratory. Weak solutions of acetic acid, as well as commerical vinegar, were found to inactivate the penetrating nematocysts of Chironex rapidly and completely. Most other substances tested proved less effective, and some actually stimulated the firing of nematocysts.

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Substances:

Year:  1980        PMID: 6102347

Source DB:  PubMed          Journal:  Med J Aust        ISSN: 0025-729X            Impact factor:   7.738


  12 in total

1.  Epidemiology of jellyfish stings presented to an American urban emergency department.

Authors:  Jennifer Ping; Neil Onizuka
Journal:  Hawaii Med J       Date:  2011-10

Review 2.  Management of marine stings and scrapes.

Authors:  C L Rosson; S W Tolle
Journal:  West J Med       Date:  1989-01

Review 3.  Interventions for the symptoms and signs resulting from jellyfish stings.

Authors:  Li Li; Richard G McGee; Geoff Isbister; Angela C Webster
Journal:  Cochrane Database Syst Rev       Date:  2013-12-09

Review 4.  Jellyfish stings and their management: a review.

Authors:  Luca Cegolon; William C Heymann; John H Lange; Giuseppe Mastrangelo
Journal:  Mar Drugs       Date:  2013-02-22       Impact factor: 5.118

5.  Envenomation by the box-jellyfish--an unusual cause of ulnar nerve palsy.

Authors:  J H Laing; D H Harrison
Journal:  J R Soc Med       Date:  1991-02       Impact factor: 18.000

6.  Firing the sting: chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) venom.

Authors:  Mahdokht Jouiaei; Nicholas R Casewell; Angel A Yanagihara; Amanda Nouwens; Bronwen W Cribb; Darryl Whitehead; Timothy N W Jackson; Syed A Ali; Simon C Wagstaff; Ivan Koludarov; Paul Alewood; Jay Hansen; Bryan G Fry
Journal:  Toxins (Basel)       Date:  2015-03-18       Impact factor: 4.546

Review 7.  Ancient Venom Systems: A Review on Cnidaria Toxins.

Authors:  Mahdokht Jouiaei; Angel A Yanagihara; Bruno Madio; Timo J Nevalainen; Paul F Alewood; Bryan G Fry
Journal:  Toxins (Basel)       Date:  2015-06-18       Impact factor: 4.546

8.  Cubozoan Sting-Site Seawater Rinse, Scraping, and Ice Can Increase Venom Load: Upending Current First Aid Recommendations.

Authors:  Angel Anne Yanagihara; Christie L Wilcox
Journal:  Toxins (Basel)       Date:  2017-03-15       Impact factor: 4.546

Review 9.  The pathology of Chironex fleckeri venom and known biological mechanisms.

Authors:  Melissa Piontek; Jamie E Seymour; Yide Wong; Tyler Gilstrom; Jeremy Potriquet; Ernest Jennings; Alan Nimmo; John J Miles
Journal:  Toxicon X       Date:  2020-02-24

10.  Experimental Assays to Assess the Efficacy of Vinegar and Other Topical First-Aid Approaches on Cubozoan (Alatina alata) Tentacle Firing and Venom Toxicity.

Authors:  Angel A Yanagihara; Christie Wilcox; Rebecca King; Kikiana Hurwitz; Ann M Castelfranco
Journal:  Toxins (Basel)       Date:  2016-01-11       Impact factor: 4.546

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