Metabolism and disposition of erythro-9-(2-hydroxy-3-nonyl)[14C]adenine in the rhesus monkey.

erythro-9-(2-Hydroxy-3-nonyl)[14C]adenine was extensively metabolized by monkeys. Following iv administration of 5 mg/kg, serum levels of total radioactivity increased to a maximum between 15 and 30 min, then dropped rapidly. Thin-layer chromatography of extracts of liver, kidney, and urine revealed four metabolites. Of the radioactivity administered, urinary excretion accounted for 70% within 6 hr and 90% within 1 week. In serum, the concentration of intact drug declined rapidly; in urine, it constituted less than 0.3% of the total radioactivity.