Literature DB >> 6101994

Mechanism for exclusion of 5-fluorouracil from DNA.

H A Ingraham, B Y Tseng, M Goulian.   

Abstract

5-Fluorodeoxyuridine 5'-triphosphate is hydrolyzed by the enzyme deoxyuridine triphosphate diphosphohydrolase (EC 3.6.1.23). Uracil-DNA glycosylase removes 5-fluorouracil (FUra) from FUra-containing DNA similar to its removal of uracil from uracil-containing DNA. The absence of FUra in DNA following exposure of cells to FUra can be explained by the activities of these two enzymes.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6101994

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  13 in total

Review 1.  DNA glycosylases in the base excision repair of DNA.

Authors:  H E Krokan; R Standal; G Slupphaug
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

2.  Systemic treatment of advanced colorectal cancer: tailoring therapy to the tumor.

Authors:  John M Carethers
Journal:  Therap Adv Gastroenterol       Date:  2008-07       Impact factor: 4.409

3.  Impairment of Pol β-related DNA base-excision repair leads to ovarian aging in mice.

Authors:  Ke Hua; Liping Wang; Junhua Sun; Nanhai Zhou; Yilan Zhang; Feng Ji; Li Jing; Yang Yang; Wen Xia; Zhigang Hu; Feiyan Pan; Xi Chen; Bing Yao; Zhigang Guo
Journal:  Aging (Albany NY)       Date:  2020-11-20       Impact factor: 5.682

Review 4.  Chemotherapeutic implications in microsatellite unstable colorectal cancer.

Authors:  Won-Seok Jo; John M Carethers
Journal:  Cancer Biomark       Date:  2006       Impact factor: 4.388

5.  Perturbations of enzymic uracil excision due to purine damage in DNA.

Authors:  N J Duker; D E Jensen; D M Hart; D E Fishbein
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

6.  Mismatch repair proficiency and in vitro response to 5-fluorouracil.

Authors:  J M Carethers; D P Chauhan; D Fink; S Nebel; R S Bresalier; S B Howell; C R Boland
Journal:  Gastroenterology       Date:  1999-07       Impact factor: 22.682

Review 7.  DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets.

Authors:  Long Shan Li; Julio C Morales; Martina Veigl; David Sedwick; Sheldon Greer; Mark Meyers; Mark Wagner; Richard Fishel; David A Boothman
Journal:  Br J Pharmacol       Date:  2009-09-23       Impact factor: 8.739

Review 8.  Participation of DNA repair in the response to 5-fluorouracil.

Authors:  M D Wyatt; D M Wilson
Journal:  Cell Mol Life Sci       Date:  2009-03       Impact factor: 9.261

Review 9.  Clinical pharmacology of 5-fluorouracil.

Authors:  R B Diasio; B E Harris
Journal:  Clin Pharmacokinet       Date:  1989-04       Impact factor: 6.447

10.  Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.

Authors:  Liyi Geng; Amelia M Huehls; Jill M Wagner; Catherine J Huntoon; Larry M Karnitz
Journal:  PLoS One       Date:  2011-12-15       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.