Literature DB >> 6101978

A comparison of the bronchoconstrictor and beta-adrenoceptor blocking activity of propranolol and acebutolol.

J MacLagan, U M Ney.   

Abstract

The bronchoconstrictor and beta-adrenoceptor blocking activity of (+/-)-propranolol, acebutolol and two of its analogues were compared in a group of littermate rats. Whilst the analogues of acebutolol had similar bronchoconstrictor potency to propranolol, acebutolol had considerably less activity. No correlation could be found between the degree of bronchoconstriction produced by the four drugs and their beta-adrenoceptor blocking activity in the airway smooth muscle. Acebutolol and its analogues show a wide properties could be related to the production of bronchospasm.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6101978      PMCID： PMC2043927          DOI： 10.1111/j.1476-5381.1980.tb10407.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  EFFECT OF A BETA-ADRENERGIC-BLOCKING AGENT, PROPRANOLOL, ON ASTHMATICS.

Authors:  R S MCNEILL
Journal:  Lancet       Date:  1964-11-21       Impact factor: 79.321

2.  An investigation into the cardiac and pulmonary beta-adrenoceptor blocking activity of ICI 66,082 in man.

Authors:  G E Marlin; C R Kumana; C M Kaye; D M Smith; P Turner
Journal:  Br J Clin Pharmacol       Date:  1975-04       Impact factor: 4.335

3.  A new series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols.

Authors:  B Basil; J R Clark; E C Coffee; R Jordon; A H Loveless; D L Pain; K R Wooldridge
Journal:  J Med Chem       Date:  1976-03       Impact factor: 7.446

4.  Selective cardiac sympathetic blockade as an adjunct to bronchodilator therapy.

Authors:  R Powles; E Shinebourne; J Hamer
Journal:  Thorax       Date:  1969-09       Impact factor: 9.139

5.  The effect of propranolol on airway resistance.

Authors:  A G Macdonald; C G Ingram; R S McNeill
Journal:  Br J Anaesth       Date:  1967-12       Impact factor: 9.166

6.  Effect of adrenergic stimulation and inhibition on human airways.

Authors:  D J Stone; T K Sarkar; H Keltz
Journal:  J Appl Physiol       Date:  1973-05       Impact factor: 3.531

7.  The effect of propranolol on the cardiovascular responses to isoprenaline, adrenaline and noradrenaline in the anaesthetized dog.

Authors:  R G Shanks
Journal:  Br J Pharmacol Chemother       Date:  1966-02

8.  Investigation of the mechanism of propranolol-induced bronchoconstriction.

Authors:  J Maclagan; U M Ney
Journal:  Br J Pharmacol       Date:  1979-07       Impact factor: 8.739
  8 in total
  2 in total

Review 1.  Acebutolol. A review of its pharmacological properties and therapeutic efficacy in hypertension, angina pectoris and arrhythmia.

Authors:  B N Singh; W R Thoden; A Ward
Journal:  Drugs       Date:  1985-06       Impact factor: 9.546

2.  Pulmonary effects in man of oral prizidilol hydrochloride (SK&F 92657), a new antihypertensive agent.

Authors:  W M Edmondstone; J F Waller; K K Manghani; P L Hill; A J Bell; D M Denison
Journal:  Br J Clin Pharmacol       Date:  1983-12       Impact factor: 4.335
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.