Literature DB >> 6101843

Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy.

J B North, R K Penhall, A Hanieh, C S Hann, R G Challen, D B Frewin.   

Abstract

In a double-blind trial of phenytoin for the prevention of postoperative epilepsy in craniotomy patients, epilepsy was observed in 7.9% (8/101) of patients treated with phenytoin and in 16.7% (17/102) of those receiving placebo. Therapeutic drug levels were associated with a significant reduction in the frequency of epilepsy. Three-quarters of the fits occurred within a month of cranial surgery. High rates of epilepsy have been observed after cranial surgery in patients with meningioma, aneurysm, and head injury with or without intracranial clots, and routine prophylaxis with phenytoin would seem to be indicated in such patients.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6101843     DOI： 10.1016/s0140-6736(80)90941-1

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  20 in total

Review 1.  Seizures and anticonvulsants after aneurysmal subarachnoid hemorrhage.

Authors:  Giuseppe Lanzino; Pietro Ivo D'Urso; Jose Suarez
Journal:  Neurocrit Care       Date:  2011-09       Impact factor: 3.210

2.  Risk factors for developing epilepsy after craniotomy in children.

Authors:  Dimitris Kombogiorgas; N Shastri Jatavallabhula; Spyros Sgouros; Vivek Josan; A Richard Walsh; Anthony D Hockley
Journal:  Childs Nerv Syst       Date:  2006-05-30       Impact factor: 1.475

3.  Do we need seizure prophylaxis for brain tumor surgery?

Authors:  Mohamad Koubeissi
Journal:  Epilepsy Curr       Date:  2014-01       Impact factor: 7.500

4.  Seizure outcomes of supratentorial brain tumor resection in pediatric patients.

Authors:  Fadi S Saadeh; Edward F Melamed; Nolan D Rea; Mark D Krieger
Journal:  Neuro Oncol       Date:  2018-08-02       Impact factor: 12.300

5.  Antiepileptic drugs as prophylaxis for postcraniotomy seizures.

Authors:  Janette Greenhalgh; Jennifer Weston; Yenal Dundar; Sarah J Nevitt; Anthony G Marson
Journal:  Cochrane Database Syst Rev       Date:  2020-04-28

6.  The incidence of postoperative seizures.

Authors:  P M Foy; G P Copeland; M D Shaw
Journal:  Acta Neurochir (Wien)       Date:  1981       Impact factor: 2.216

7.  Intravenous phenytoin loading in patients after neurosurgery and in status epilepticus. A population pharmacokinetic study.

Authors:  S Vozeh; T Uematsu; L Aarons; P Maitre; H Landolt; O Gratzl
Journal:  Clin Pharmacokinet       Date:  1988-02       Impact factor: 6.447

Review 8.  Seizure prophylaxis for brain tumour patients. Brief review and guide for family physicians.

Authors:  C B Agbi; M Bernstein
Journal:  Can Fam Physician       Date:  1993-05       Impact factor: 3.275

9.  Epilepsy following brain abscess. The evaluation of possible risk factors with emphasis on new concept of epileptic focus formation.

Authors:  W Koszewski
Journal:  Acta Neurochir (Wien)       Date:  1991       Impact factor: 2.216

10.  A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors.

Authors:  Adam S Wu; Victoria T Trinh; Dima Suki; Susan Graham; Arthur Forman; Jeffrey S Weinberg; Ian E McCutcheon; Sujit S Prabhu; Amy B Heimberger; Raymond Sawaya; Xuemei Wang; Wei Qiao; Kenneth Hess; Frederick F Lang
Journal:  J Neurosurg       Date:  2013-02-08       Impact factor: 5.115
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.