| Literature DB >> 6101751 |
L E Simmons, J D Abbott, M E Macaulay, A E Jones, A G Ironside, B K Mandal, T N Stanbridge, P Maximescu.
Abstract
A toxigenic strain of Corynebacterium diphtheriae mitis was isolated from a 10-week-old baby with membranous tonsillitis, and over the next 6 months thirty-nine symptom-free carriers of nitrate-positive mitis strains were found. All carriers were cleared by 14 days' treatment with erythromycin, though several relapsed after a 5-day course. Four contacts carried both toxigenic and non-toxigenic mitis strains; epidemiological evidence and phage studies suggest that these had a common origin. These findings have implications for the epidemiology of diphtheria and for the routine testing of isolates for toxigenicity.Entities:
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Year: 1980 PMID： 6101751 DOI： 10.1016/s0140-6736(80)90793-x
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321