Literature DB >> 6101750

Epstein-Barr-virus-induced oncogenesis in immune-deficient individuals.

D T Purtilo.   

Abstract

Experimental and clinical evidence supports the notion that the Epstein-Barr virus (EBV) can become oncogenic in immune-deficient hosts. Renal transplant recipients and children with inherited immune deficiency are at high risk for lymphomagenesis. Defective immune responses to EBV permit persistence of polyclonal proliferation of B cells. Conversion from polyclonal to monoclonal proliferation is probably the result of a cytogenetic error in a B cell. This hypothesis can be tested prospectively in patients with immune deficiency by immunological, EBV, and genetic studies.

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Year:  1980        PMID： 6101750     DOI： 10.1016/s0140-6736(80)90792-8

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  33 in total

Review 1.  X-linked lymphoproliferative disease (XLP) as a model of Epstein-Barr virus-induced immunopathology.

Authors:  D T Purtilo
Journal:  Springer Semin Immunopathol       Date:  1991

2.  [Hodgkin's disease following kidney transplantation with cyclosporin A].

Authors:  K Görg; C Görg; K Havemann; H Lange
Journal:  Klin Wochenschr       Date:  1986-07-15

3.  Cyclosporin A: pharmacologic activity on the immune system and effects in clinical organ transplantation.

Authors:  L H Block; P M Sutter; M J Mihatsch
Journal:  Klin Wochenschr       Date:  1983-11-02

4.  Acquired immunodeficiency syndrome in a patient with no known risk factors: a pathological study.

Authors:  A D Burt; G Scott; C R Shiach; C G Isles
Journal:  J Clin Pathol       Date:  1984-04       Impact factor: 3.411

5.  Establishment of spontaneously outgrowing lymphoblastoid cell lines with Cyclosporin A.

Authors:  M von Knebel Doeberitz; G W Bornkamm; H zur Hausen
Journal:  Med Microbiol Immunol       Date:  1983       Impact factor: 3.402

6.  The systemic distribution of Epstein-Barr virus genomes in fatal post-transplantation lymphoproliferative disorders. An in situ hybridization study.

Authors:  P S Randhawa; R Jaffe; A J Demetris; M Nalesnik; T E Starzl; Y Y Chen; L M Weiss
Journal:  Am J Pathol       Date:  1991-04       Impact factor: 4.307

7.  Clinicopathological and Immunohistochemical Study of Head and Neck Langerhans Cell Histiocytosis from Latin America.

Authors:  Natália Rocha Bedran; Román Carlos; Bruno Augusto Benevenuto de Andrade; Ana Paula Silva Bueno; Mário José Romañach; Cristiane Bedran Milito
Journal:  Head Neck Pathol       Date:  2017-11-21

8.  Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.

Authors:  R P Custer; G C Bosma; M J Bosma
Journal:  Am J Pathol       Date:  1985-09       Impact factor: 4.307

9.  A prospective study on infectious mononucleosis in childhood--symptoms, serology, Epstein-Barr-Virus specific leukocyte migration inhibition.

Authors:  L Timár; J Budai; M Koller
Journal:  Infection       Date:  1982       Impact factor: 3.553

10.  EBV LMP2A affects LMP1-mediated NF-kappaB signaling and survival of lymphoma cells by regulating TRAF2 expression.

Authors:  Ilaria Guasparri; Darya Bubman; Ethel Cesarman
Journal:  Blood       Date:  2008-01-29       Impact factor: 22.113
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