Literature DB >> 6101356

Fibroblast nitroblue tetrazolium test and the in-utero diagnosis of chronic granulomatous disease.

S M Fikrig, E M Smithwick, K Suntharalingam, R A Good.   

Abstract

A quantitative nitroblue tetrazolium (NBT) test was devised to measure dye reduction by fibroblasts. Statistically significant differences were found between NBT reduction by normal skin and amniotic fibroblasts and by skin fibroblasts of male patients with chronic granulomatous disease (CGD) and their carrier relatives. Cultured amniotic cells may therefore be useful in the prenatal diagnosis of X-linked CGD.

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Year:  1980        PMID: 6101356     DOI: 10.1016/s0140-6736(80)90554-1

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  3 in total

1.  Pneumocystis carinii: oxygen uptake, antioxidant enzymes, and susceptibility to oxygen-mediated damage.

Authors:  E L Pesanti
Journal:  Infect Immun       Date:  1984-04       Impact factor: 3.441

2.  The cytochrome b-558 molecules involved in the fibroblast and polymorphonuclear leucocyte superoxide-generating NADPH oxidase systems are structurally and genetically distinct.

Authors:  B Meier; A J Jesaitis; A Emmendörffer; J Roesler; M T Quinn
Journal:  Biochem J       Date:  1993-01-15       Impact factor: 3.857

Review 3.  Chronic granulomatous disease, a heterogeneous syndrome.

Authors:  W H Hitzig; R A Seger
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

  3 in total

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