Literature DB >> 6101160

Transport in quantitative structure-activity relationships. VI: Relationship between transport rate constants and partition coefficients.

H van de Waterbeemd1, P van Bakel, A Jansen.   

Abstract

The transport rate constant of a drug partitioned in a two-phase system from an aqueous to an organic phase (k1obs) and vice versa (k2obs) is a function of the partition coefficient P and of a solvent system-dependent parameter beta. Drug transport is shown to be independent of molecular structure for a number of arbitrary compounds.

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Year:  1981        PMID： 6101160     DOI： 10.1002/jps.2600700930

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  4 in total

Review 1.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

2.  The determination of interfacial transfer constants using side-by-side diffusion cells.

Authors:  G L Mosher
Journal:  Pharm Res       Date:  1994-09       Impact factor: 4.200

3.  Transport in QSAR VIII. The influence of viscosity on transport rate constants in two-phase systems organic solvent-water.

Authors:  F H De Haan; A C Jansen
Journal:  Pharm Weekbl Sci       Date:  1983-10-21

4.  Structural determinants of drug partitioning in n-hexadecane/water system.

Authors:  Senthil Natesan; Zhanbin Wang; Viera Lukacova; Ming Peng; Rajesh Subramaniam; Sandra Lynch; Stefan Balaz
Journal:  J Chem Inf Model       Date:  2013-05-21       Impact factor: 4.956
  4 in total

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