Literature DB >> 6098878

Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain stimulation reward.

F J Vaccarino, G F Koob.   

Abstract

Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide (CCK-8S) into the nucleus accumbens were examined for effects on intracranial self-stimulation (ICSS) derived from the ventral tegmental area (VTA). The results showed that CCK-8S dose-dependently antagonized VTA intracranial self-stimulation (ICSS) without affecting maximum response rates. CCK-8S also increased the current threshold required for ICSS. These findings were interpreted to suggest that CCK-8S attenuates brain stimulation reward derived from the VTA.

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Year:  1984        PMID： 6098878     DOI： 10.1016/0304-3940(84)90351-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  8 in total

1.  Effect of intracerebroventricular and systemic injections of caerulein, a CCK analogue, on electrical self-stimulation and its interaction with the CCKA receptor antagonist, L-364,718 (MK-329).

Authors:  M H Hamilton; I C Rose; L J Herberg; J S de Belleroche
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

2.  CCK-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-OHDA and chronic-neuroleptic treated rats.

Authors:  F Weiss; A Ettenberg; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

3.  GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake.

Authors:  Amber L Alhadeff; Laura E Rupprecht; Matthew R Hayes
Journal:  Endocrinology       Date:  2011-11-29       Impact factor: 4.736

4.  Infusions of cholecystokinin octapeptide into the ventral tegmental area potentiate amphetamine conditioned place preferences.

Authors:  H O Pettit; K Mueller
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

5.  Effect of CCK receptor antagonists on the antinociceptive, reinforcing and gut motility properties of morphine.

Authors:  L Singh; R J Oles; M J Field; P Atwal; G N Woodruff; J C Hunter
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

6.  Cholecystokinin activates CCKB receptors to excite cells and depress EPSCs in the rat rostral nucleus accumbens in vitro.

Authors:  Samuel B Kombian; Kethireddy V V Ananthalakshmi; Subramanian S Parvathy; Wandikayi C Matowe
Journal:  J Physiol       Date:  2003-12-12       Impact factor: 5.182

7.  Facilitation and inhibition of feeding by a single dose of amphetamine: relationship to baseline intake and accumbens cholecystokinin.

Authors:  T L Sills; F J Vaccarino
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

8.  Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats.

Authors:  Z B You; T M Tzschentke; E Brodin; R A Wise
Journal:  J Neurosci       Date:  1998-08-15       Impact factor: 6.167
  8 in total

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