Literature DB >> 6098849

A brain octadecaneuropeptide generated by tryptic digestion of DBI (diazepam binding inhibitor) functions as a proconflict ligand of benzodiazepine recognition sites.

P Ferrero, A Guidotti, B Conti-Tronconi, E Costa.   

Abstract

An octadecaneuropeptide (ODN) produced by the tryptic digestion of DBI was purified and sequenced and its activity on the Vogel test determined. In vitro ODN displaces 3H-diazepam from specific brain recognition sites and injected intraventricularly in thirsty rats facilitates the onset of behavioral inhibition elicited by punishment. The alpha-amide derivative of ODN is devoid of either action. Evidence is presented suggesting that DBI sequence includes at least two replicas of ODN or one replica of ODN and a fragment with similar if not identical amino acid sequence but identical biological activity.

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Year:  1984        PMID： 6098849     DOI： 10.1016/0028-3908(84)90061-3

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  16 in total

1.  Putative diazepam binding inhibitor peptide: cDNA clones from rat.

Authors:  I Mocchetti; R Einstein; J Brosius
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

2.  Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain.

Authors:  L Sangameswaran; H M Fales; P Friedrich; A L De Blas
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

3.  Decreased benzodiazepine receptor binding in epileptic El mice: a quantitative autoradiographic study.

Authors:  Y Shirasaka; M Ito; H Tsuda; H Shiraishi; K Oguro; K Mutoh; H Mikawa
Journal:  Neurochem Res       Date:  1990-09       Impact factor: 3.996

4.  Isolation and identification in bovine cerebral cortex of n-butyl beta-carboline-3-carboxylate, a potent benzodiazepine binding inhibitor.

Authors:  C Peña; J H Medina; M L Novas; A C Paladini; E De Robertis
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

5.  Diazepam binding inhibitor (DBI) processing: immunohistochemical studies in the rat brain.

Authors:  H Alho; P Bovolin; E Slobodyansky
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

6.  Early developmental exposure to benzodiazepine ligands alters brain levels of thiobarbituric acid-reactive products in young adult rats.

Authors:  R C Miranda; J P Wagner; C K Kellogg
Journal:  Neurochem Res       Date:  1989-11       Impact factor: 3.996

7.  Chromosomal localization of the human diazepam binding inhibitor gene.

Authors:  M A DeBernardi; R R Crowe; I Mocchetti; T B Shows; R L Eddy; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

8.  Tissue-specific expression of the diazepam-binding inhibitor in Drosophila melanogaster: cloning, structure, and localization of the gene.

Authors:  M Kolmer; C Roos; M Tirronen; S Myöhänen; H Alho
Journal:  Mol Cell Biol       Date:  1994-10       Impact factor: 4.272

9.  Demonstration of benzodiazepine-like molecules in the mammalian brain with a monoclonal antibody to benzodiazepines.

Authors:  L Sangameswaran; A L de Blas
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

10.  Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.

Authors:  P Ferrero; M R Santi; B Conti-Tronconi; E Costa; A Guidotti
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205
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