Literature DB >> 6098836

Inhibition via opioid mu- and delta-receptors of vagal transmission in rabbit isolated heart.

R Weitzell, P Illes, K Starke.   

Abstract

The nervi vagi of isolated perfused rabbit hearts were stimulated by 10 s trains of electrical pulses at 1, 2 or 5 Hz. Morphine, Met-enkephalin and D-Ala2,D-Leu5-enkephalin reduced the ensuing bradycardia with IC50 values of 148, 25 and 3.2 nM, respectively. Naloxone antagonized the effects of morphine and Met-enkephalin; KB values (dissociation constants of antagonist-receptor complex) were 1.1 and 33 nM, respectively. The delta-receptor-selective antagonist ICI 174864 antagonized Met-enkephalin, KB 28 nM, but at 0.2 microM did not antagonize morphine. It is concluded that vagal transmission to the rabbit heart can be inhibited by activation of both opioid mu- und delta-receptors.

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Year:  1984        PMID： 6098836     DOI： 10.1007/bf00512070

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  12 in total

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Journal:  Rev Physiol Biochem Pharmacol       Date:  1977       Impact factor: 5.545

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Authors:  W S Young; J K Wamsley; M A Zarbin; M J Kuhar
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Authors:  K Starke
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6.  Increase in potencies of opioid peptides after peptidase inhibition.

Authors:  A T McKnight; A D Corbett; H W Kosterlitz
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7.  ICI 174864: a highly selective antagonist for the opioid delta-receptor.

Authors:  R Cotton; M G Giles; L Miller; J S Shaw; D Timms
Journal:  Eur J Pharmacol       Date:  1984-01-27       Impact factor: 4.432

Review 8.  Classification of opioid receptors.

Authors:  S J Paterson; L E Robson; H W Kosterlitz
Journal:  Br Med Bull       Date:  1983-01       Impact factor: 4.291

9.  Effect of morphine on electrically-induced release of autonomic mediators in the rabbit sinoatrial node.

Authors:  B L Kennedy; T C West
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10.  Endogenous opioid peptides: multiple agonists and receptors.

Authors:  J A Lord; A A Waterfield; J Hughes; H W Kosterlitz
Journal:  Nature       Date:  1977-06-09       Impact factor: 49.962
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Authors:  H Fuder; M Buder; H D Riers; G Rothacher
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Review 6.  Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists.

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8.  Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block.

Authors:  Phu N Tran; Jiansong Sheng; Aaron L Randolph; Claudia Alvarez Baron; Nicolas Thiebaud; Ming Ren; Min Wu; Lars Johannesen; Donna A Volpe; Dakshesh Patel; Ksenia Blinova; David G Strauss; Wendy W Wu
Journal:  PLoS One       Date:  2020-11-06       Impact factor: 3.240
  8 in total

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