Literature DB >> 6098346

Autoradiographic distribution of nicotine receptors in rat brain.

P B Clarke, C B Pert, A Pert.   

Abstract

The autoradiographic visualisation of 90%-specific tritiated nicotine binding to slide-mounted sections of rat brain is reported. Tritiated nicotine bound with high affinity (nanomolar Kd) and was selectively displaced by nicotinic agonists (e.g. L-nicotine approximately ACh greater than D-nicotine). The strikingly discrete distribution pattern obtained deviates from that of alpha-bungarotoxin, and suggests several possible roles for nicotinic transmission in the brain.

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Year:  1984        PMID： 6098346     DOI： 10.1016/0006-8993(84)90320-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  39 in total

1.  Differential effects of M1 muscarinic receptor blockade and nicotinic receptor blockade in the dorsomedial striatum on response reversal learning.

Authors:  Arianna Tzavos; Jane Jih; Michael E Ragozzino
Journal:  Behav Brain Res       Date:  2004-09-23       Impact factor: 3.332

2.  TC-2559 excites dopaminergic neurones in the ventral tegmental area by stimulating alpha4beta2-like nicotinic acetylcholine receptors in anaesthetised rats.

Authors:  Yun Wang; John L Sherwood; Colin P Miles; Gary Whiffin; David Lodge
Journal:  Br J Pharmacol       Date:  2006-02       Impact factor: 8.739

3.  Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior.

Authors:  Alexander Kuzmin; Elisabet Jerlhag; Sture Liljequist; Jörgen Engel
Journal:  Psychopharmacology (Berl)       Date:  2008-11-06       Impact factor: 4.530

4.  Release of met-enkephalin and its modulation through acetylcholine receptors in the rabbit superior colliculus.

Authors:  R B Illing; K E Nikolarakis; T Wichmann; W B Spatz; K Starke
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

5.  Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs.

Authors:  D Goldman; D Simmons; L W Swanson; J Patrick; S Heinemann
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

6.  Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol.

Authors:  Zheng-Ming Ding; Simon N Katner; Zachary A Rodd; William Truitt; Sheketha R Hauser; Gerald A Deehan; Eric A Engleman; William J McBride
Journal:  Alcohol       Date:  2012-03-25       Impact factor: 2.405

7.  Electrophysiological actions of nicotine on substantia nigra single units.

Authors:  P B Clarke; D W Hommer; A Pert; L R Skirboll
Journal:  Br J Pharmacol       Date:  1985-08       Impact factor: 8.739

Review 8.  The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum.

Authors:  Sharon R Grady; Outi Salminen; Duncan C Laverty; Paul Whiteaker; J Michael McIntosh; Allan C Collins; Michael J Marks
Journal:  Biochem Pharmacol       Date:  2007-07-27       Impact factor: 5.858

Review 9.  In vivo brain imaging of human exposure to nicotine and tobacco.

Authors:  Anil Sharma; Arthur L Brody
Journal:  Handb Exp Pharmacol       Date:  2009

10.  Nicotinic systems and cognitive function.

Authors:  E D Levin
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530
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