Literature DB >> 6097967

The chloride channel opening by GABA as an energy dependent process.

C M Sánchez, M C Toledo, M P González.   

Abstract

4-aminobutyric acid (GABA) induced an increase in the chloride ion uptake into synaptosomes from rat brain. The synaptosomal fraction used maintained its integrity and metabolic functionality. The chloride uptake was potentiated by the presence of succinate, reaching an increase of 46.5% and 76.4% without or with ADP respectively. These results were parallel to those obtained in the assays of oxygen consumption. These results suggest the energy dependence of the chloride uptake process.

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Year:  1984        PMID: 6097967

Source DB:  PubMed          Journal:  Rev Esp Fisiol        ISSN: 0034-9402


  3 in total

1.  Transmembrane flux and receptor desensitization measured with membrane vesicles. Homogeneity of vesicles investigated by computer simulation.

Authors:  D J Cash; R M Langer; K Subbarao; J R Bradbury
Journal:  Biophys J       Date:  1988-11       Impact factor: 4.033

2.  Responses of gamma-aminobutyrate receptor from rat brain: similarity of different preparation methods; muscimol induced desensitization and chloride exchange.

Authors:  D J Cash; K Subbarao
Journal:  J Membr Biol       Date:  1989-11       Impact factor: 1.843

3.  Use of 82Br- radiotracer to study transmembrane halide flux: the effect of a tranquilizing drug, chlordiazepoxide on channel opening of a GABAA receptor.

Authors:  D J Cash; P Serfözö; K Zinn
Journal:  J Membr Biol       Date:  1995-06       Impact factor: 1.843

  3 in total

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