| Literature DB >> 6097322 |
C Hamelin, L Cousineau, M Dion, J Yelle.
Abstract
Chromatin-associated DNA topoisomerase I activity was measured in human diploid fibroblasts during in vitro aging. No difference was detected as a function of cell age in the nicking and the closing activities of the DNA-unwinding enzyme. The capacity of type-I topoisomerase to relax superhelical DNA molecules was, however, increased in aged cells. An age-related increase in nucleoprotein content was also observed.Entities:
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Year: 1984 PMID： 6097322 DOI： 10.1007/bf01138168
Source DB: PubMed Journal: Biosci Rep ISSN： 0144-8463 Impact factor: 3.840