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Literature DB >> 6097319

Ionic channels in a line of embryonal carcinoma cells induced to undergo neuronal differentiation.

Abstract

The gigaseal patch clamp technique was used to investigate the electrophysiological properties of a line of embryonal carcinoma cells (PCC4) that were induced to undergo neuronal differentiation. A large increase in number of voltage-dependent potassium and sodium channels was observed during differentiation. The pharmacology and kinetics of the macroscopic sodium and potassium currents in the differentiated cells closely resembled those of the rapid inward sodium current and the delayed rectifier, respectively. The kinetic behavior of single-channel potassium currents was consistent with the properties of the macroscopic delayed rectifier current.

Entities: Chemical Disease

Mesh：

Substances：
Ion Channels

Year: 1984 PMID： 6097319 PMCID： PMC1435111 DOI： 10.1016/S0006-3495(84)84081-3

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

11 in total

1. Effect of internal fluoride and phosphate on membrane currents during intracellular dialysis of nerve cells.

Authors: P G Kostyuk; O A Krishtal; V I Pidoplichko
Journal: Nature Date: 1975-10-23 Impact factor: 49.962

2. The Leeuwenhoek Lecture, 1977. Mouse teratocarcinoma and mouse embryo.

Authors: F Jacob
Journal: Proc R Soc Lond B Biol Sci Date: 1978-05-16

3. Single potassium channels with delayed rectifier behavior from lobster axon membranes.

Authors: R Coronado; R Latorre; H G Mautner
Journal: Biophys J Date: 1984-01 Impact factor: 4.033

4. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

Authors: T E DeCoursey; K G Chandy; S Gupta; M D Cahalan
Journal: Nature Date: 1984 Feb 2-8 Impact factor: 49.962

5. Single channel recordings of K+ currents in squid axons.

Authors: F Conti; E Neher
Journal: Nature Date: 1980-05-15 Impact factor: 49.962

6. Ionic currents in cultured mouse neuroblastoma cells under voltage-clamp conditions.

Authors: W H Moolenaar; I Spector
Journal: J Physiol Date: 1978-05 Impact factor: 5.182

7. Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells.

Authors: A N Theofilopoulos; D A Carson; M Tavassoli; S F Slovin; W C Speers; F B Jensen; J H Vaughan
Journal: Arthritis Rheum Date: 1980-01

8. Nerve growth factor induces adrenergic neuronal differentiation in F9 teratocarcinoma cells.

Authors: P Liesi; L Rechardt; J Wartiovaara
Journal: Nature Date: 1983 Nov 17-23 Impact factor: 49.962

9. In vitro differentiation of mouse teratocarcinoma cells monitored by intermediate filament expression.

Authors: D Paulin; H Jakob; F Jacob; K Weber; M Osborn
Journal: Differentiation Date: 1982 Impact factor: 3.880

10. Differentiation of a teratocarcinoma line: preferential development of cholinergic neurons.

Authors: S E Pfeiffer; H Jakob; K Mikoshiba; P Dubois; J L Guenet; J F Nicolas; J Gaillard; G Chevance; F Jacob
Journal: J Cell Biol Date: 1981-01 Impact factor: 10.539

6 in total

1. Characterization of a delayed rectifier K+ channel in NG108-15 neuroblastoma X glioma cells: gating kinetics and the effects of enrichment of membrane phospholipids with arachidonic acid.

Authors: R McGee; M S Sansom; P N Usherwood
Journal: J Membr Biol Date: 1988-04 Impact factor: 1.843

2. Development of ion channels and neurofilaments during neuronal differentiation of mouse embryonal carcinoma cell lines.

Authors: Y Kubo
Journal: J Physiol Date: 1989-02 Impact factor: 5.182