Literature DB >> 6097297

Successful chemotherapy with deoxycoformycin in adult T-cell lymphoma-leukaemia.

S Daenen, R A Rojer, J W Smit, M R Halie, H O Nieweg.   

Abstract

A patient from the Caribbean area with active T-cell lymphoma-leukaemia was primarily treated with deoxycoformycin (DCF), 5 mg/m2 i.v. on 3 consecutive days, followed by 5 mg/m2 i.v. weekly. A complete remission was attained and maintained during several weeks with DCF. A single consolidation course with other cytostatics was then given. The patient continues in complete remission without further therapy, 24 months after diagnosis, 17 months after the last cytostatic drugs. T-cell lymphoma-leukaemia has a bad prognosis with conventional anti-lymphoma therapy but was exquisitely sensitive to DCF in this patient.

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Year:  1984        PMID: 6097297     DOI: 10.1111/j.1365-2141.1984.tb06119.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN: 0007-1048            Impact factor:   6.998


  8 in total

1.  Spontaneous remission and relapse in adult T cell lymphoma/leukaemia associated with HTLV-I.

Authors:  C Mattock; N A Anderson; C D Sheldon; M H Rustin; B I Hoffbrand
Journal:  Br Med J (Clin Res Ed)       Date:  1986-05-03

2.  HTLV-I-associated diseases.

Authors:  P A Bunn
Journal:  West J Med       Date:  1989-05

3.  Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109).

Authors:  Kunihiro Tsukasaki; Kensei Tobinai; Masanori Shimoyama; Mitsuo Kozuru; Naokuni Uike; Yasuaki Yamada; Masao Tomonaga; Koichi Araki; Masaharu Kasai; Kiyoshi Takatsuki; Mitsutoshi Tara; Chikara Mikuni; Tomomitsu Hotta
Journal:  Int J Hematol       Date:  2003-02       Impact factor: 2.490

Review 4.  Enzymes of purine metabolism in lymphoid neoplasms, clinical relevance for treatment with enzyme inhibitors.

Authors:  A D Ho; K Ganeshaguru
Journal:  Klin Wochenschr       Date:  1988-06-01

Review 5.  Adult T-cell leukemia-lymphoma.

Authors:  S M Neely
Journal:  West J Med       Date:  1989-05

Review 6.  Pentostatin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in lymphoproliferative disorders.

Authors:  R N Brogden; E M Sorkin
Journal:  Drugs       Date:  1993-10       Impact factor: 9.546

7.  Potentiation of growth-inhibitory activity of 9-beta-D-arabinofuranosyladenine by 2'-deoxycoformycin in human cultured cell lines derived from leukemias and lymphomas.

Authors:  Y Kuroki; M Shimoyama; S Inaba; M Hirose
Journal:  Jpn J Cancer Res       Date:  1989-05

Review 8.  Current status of therapeutic approaches to adult T-cell leukemia.

Authors:  Takayuki Ishikawa
Journal:  Int J Hematol       Date:  2003-11       Impact factor: 2.319

  8 in total

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