Literature DB >> 6096726

Effect of pithing on the postjunctional sympatho-inhibitory action of captopril in cats.

A de Jonge, D Davidesko, M J Mathy, M J Thoolen, B Wilffert, P van Brummelen, P B Timmermans, P A van Zwieten.   

Abstract

Pithing of anaesthetized normotensive cats significantly lowered the arterial blood pressure and augmented plasma renin activity (PRA). Captopril dose-dependently diminished mean arterial blood pressure in both pithed and intact anaesthetized normotensive cats. The hypotensive effectiveness of captopril was most pronounced in pithed cats. Captopril inhibited the hypertensive response to intravenously administered noradrenaline in pithed cats, but did not attenuate the hypertensive response to noradrenaline in intact cats. The results do not exclude that the hypotensive activity of captopril in intact cats may be causally independent of the attenuating effect of converting enzyme inhibition on the postjunctional alpha-adrenoceptor mediated vasoconstriction as observed in pithed animals.

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Year:  1984        PMID： 6096726     DOI： 10.1007/bf00496101

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  13 in total

1.  The question of vascular hyper-responsiveness in hypertension.

Authors:  P D REDLEAF; L TOBIAN
Journal:  Circ Res       Date:  1958-03       Impact factor: 17.367

2.  Interaction of angiotensin II with noradrenaline and other spasmogens on rabbit isolated aortic strips.

Authors:  M D Day; A F Moore
Journal:  Arch Int Pharmacodyn Ther       Date:  1976-01

3.  Potentiation of the effects of noradrenaline and of sympathetic stimulation of the perfused rat caudal artery by angiotensin.

Authors:  T E Nicholas
Journal:  J Pharm Pharmacol       Date:  1970-01       Impact factor: 3.765

4.  Captopril impairs the vascular smooth muscle contraction mediated by postsynaptic alpha 2-adrenoceptors in the pithed rat.

Authors:  A De Jonge; B Wilffert; H O Kalkman; J C Van Meel; M J Thoolen; P B Timmermans; P A Van Zwieten
Journal:  Eur J Pharmacol       Date:  1981-09-24       Impact factor: 4.432

5.  Effects of continuous angiotensin I-converting enzyme blockade on blood pressure, sympathetic activity and renin-angiotensin system in stroke-prone spontaneously hypertensive rats.

Authors:  F M Lai; T Tanikella; H Herzlinger; L Thibault; P Cervoni
Journal:  Life Sci       Date:  1981-03-23       Impact factor: 5.037

6.  Some statistical methods useful in circulation research.

Authors:  S Wallenstein; C L Zucker; J L Fleiss
Journal:  Circ Res       Date:  1980-07       Impact factor: 17.367

7.  Hypotensive action of captopril in spontaneously hypertensive and normotensive rats. Interference with neurogenic vasoconstriction.

Authors:  D P Clough; R Hatton; J R Keddie; M G Collis
Journal:  Hypertension       Date:  1982 Nov-Dec       Impact factor: 10.190

8.  Pre- and postjunctional inhibition of vascular sympathetic function by captopril in SHR. Implication of vascular angiotensin II in hypertension and antihypertensive actions of captopril.

Authors:  M J Antonaccio; L Kerwin
Journal:  Hypertension       Date:  1981 May-Jun       Impact factor: 10.190

9.  Pressor responses to norepinephrine in rabbits with 3-day and 30-day renal artery stenosis. The role of angiotensin II.

Authors:  S Ichikawa; J A Johnson; W L Fowler; C G Payne; K Kurz; W F Keitzer
Journal:  Circ Res       Date:  1978-09       Impact factor: 17.367

10.  Effect of captopril on sympathetic neurotransmission in pithed normotensive rats.

Authors:  A De Jonge; J T Knape; J C Van Meel; H O Kalkman; B Wilffert; M J Thoolen; P Van Brummelen; P B Timmermans; P A Van Zwieten
Journal:  Eur J Pharmacol       Date:  1983-03-25       Impact factor: 4.432
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  1 in total

1.  Chronic treatment of the spontaneously hypertensive rat with captopril attenuates responses to noradrenaline in vivo but not in vitro.

Authors:  J Atkinson; M Sonnay; M Sautel; A K Fouda
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-06       Impact factor: 3.000
  1 in total

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