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Literature DB >> 6096160

Purification from human plasma of endogenous sodium transport inhibitor(s).

J F Cloix, G Dagher, M Crabos, M G Pernollet, P Meyer.

Abstract

Na+,K+-ATPase inhibitors extracted from plasma of healthy human subjects displaced 3H-ouabain binding to human erythrocytes and inhibited the Na+ efflux catalyzed by the Na+,K+-pump and unexpectedly the Na+,K+-cotransport system without alteration of the Na+,Na+-exchange or the Na+ passive permeability. This suggests the presence in healthy human plasma of endogenous factors with ouabain-like and furosemide-like activities.

Entities: Chemical Species

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Year: 1984 PMID： 6096160 DOI： 10.1007/bf01951899

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

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Authors: J C Ellory; G W Stewart
Journal: Br J Pharmacol Date: 1982-01 Impact factor: 8.739

Purification from human plasma of endogenous sodium transport inhibitor(s).

1. The sodium pump.

Review 2. Mechanism of action of digitalis glycosides at the subcellular level.

3. Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay.

4. Evidence against Na+-pump mediation of Ca2+-activated K+ transport and diuretic-sensitive (Na+/K+)-cotransport.

5. Endogenous digitalis-like substance in plasma of volume-expanded dogs.

6. The human erythrocyte Cl-dependent Na-K cotransport system as a possible model for studying the action of loop diuretics.

7. A Na+,K+ co-transport assay for essential hypertension.

8. Membrane potential changes induced by the ouabain-like compound extracted from mammalian brain.

9. Evidence for a raised concentration of a circulating sodium transport inhibitor in essential hypertension.

10. Progress in isolation and purification of an inhibitor of sodium transport obtained from dog urine.