Literature DB >> 6096147

Is the relative 99mTc-DMSA clearance a useful marker of proximal tubular dysfunction?

W H van Luijk, G J Ensing, S Meijer, A J Donker, D A Piers.   

Abstract

The clearance of 125I-sodium iothalamate, 131I-sodium hippurate, 99mTc-DMSA, and beta 2-microglobulin were determined in 20 patients with proven or suspected proximal tubular dysfunction and in 18 control patients with various renal diseases. A clear distinction in the relative 99mTc-DMSA clearance was observed between patients with proximal tubulopathy (14%-35%) and control patients (less than 14%). A similar difference between the two groups was found in the relative beta 2-microglobulin clearance. Nine patients with proximal tubulopathy showed an elevated filtration fraction versus only two control patients. The renal handling of 99mTc-DMSA seems to be an indicator of proximal tubular function.

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Year:  1984        PMID： 6096147     DOI： 10.1007/bf00563165

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  12 in total

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2.  Serum 2 -microglobulin in renal disease.

Authors:  L Wibell; P E Evrin; I Berggård
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4.  Low renal uptake of 99mTc-DMSA in patients with proximal tubular dysfunction.

Authors:  W H van Luÿk; G J Ensing; D A Piers
Journal:  Eur J Nucl Med       Date:  1983

5.  Rapid miniaturized chromatographic quality-control procedures for Tc-99m radiopharmaceuticals.

Authors:  A M Zimmer; D G Pavel
Journal:  J Nucl Med       Date:  1977-12       Impact factor: 10.057

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Journal:  Radiat Res       Date:  1977-03       Impact factor: 2.841

7.  A clinical study of 99mTechnetium dimercaptosuccinic acid uptake in obstructed kidneys: comparison with the creatinine clearance.

Authors:  P De Maeyer; M Simons; W Oosterlinck; W A De Sy
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9.  Tc-99m DMSA renal uptake: influence of biochemical and physiologic factors.

Authors:  C A Yee; H B Lee; M D Blaufox
Journal:  J Nucl Med       Date:  1981-12       Impact factor: 10.057

10.  Renal tubular handling of drugs.

Authors:  E J Cafruny
Journal:  Am J Med       Date:  1977-04       Impact factor: 4.965
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Journal:  Eur J Nucl Med       Date:  1990

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5.  Decreased renal uptake of (99m)Tc-DMSA in patients with tubular proteinuria.

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6.  Two routes for 99mTc-DMSA uptake into the renal cortical tubular cell.

Authors:  A M Peters; D H Jones; K Evans; I Gordon
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  7 in total

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