Literature DB >> 6095870

IgG and IgM antibody to native type II collagen in rheumatoid arthritis serum and synovial fluid. Evidence for the presence of collagen-anticollagen immune complexes in synovial fluid.

R B Clague, L J Moore.   

Abstract

Levels of IgG and IgM antibody to native type II collagen, a component of articular cartilage, were measured by a specific solid-phase radioimmunoassay, in 48 rheumatoid arthritis patients. Good correlations were found between the levels in sera and those in synovial fluids. Collagenase digestion caused a significant rise in specific antibody levels in synovial fluids, indicating the presence of intraarticular collagen-anticollagen complexes. These immune complexes may be one mechanism for perpetuation of inflammation in some rheumatoid arthritis patients.

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Year:  1984        PMID： 6095870     DOI： 10.1002/art.1780271207

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  16 in total

1.  Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.

Authors:  E C Andersson; B E Hansen; H Jacobsen; L S Madsen; C B Andersen; J Engberg; J B Rothbard; G S McDevitt; V Malmström; R Holmdahl; A Svejgaard; L Fugger
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-23       Impact factor: 11.205

Review 2.  What do anti-collagen antibodies mean?

Authors:  K Morgan
Journal:  Ann Rheum Dis       Date:  1990-01       Impact factor: 19.103

3.  The role of lipopolysaccharide injected systemically in the reactivation of collagen-induced arthritis in mice.

Authors:  S Yoshino; M Ohsawa
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

Review 4.  Antibody-dependent and -independent mechanisms of inflammatory arthritis.

Authors:  Margaret H Chang; Peter A Nigrovic
Journal:  JCI Insight       Date:  2019-03-07

5.  Complement C1s activation in degenerating articular cartilage of rheumatoid arthritis patients: immunohistochemical studies with an active form specific antibody.

Authors:  K Nakagawa; H Sakiyama; T Tsuchida; K Yamaguchi; T Toyoguchi; R Masuda; H Moriya
Journal:  Ann Rheum Dis       Date:  1999-03       Impact factor: 19.103

6.  Bacterial lipopolysaccharide acts as an adjuvant to induce autoimmune arthritis in mice.

Authors:  S Yoshino; E Sasatomi; M Ohsawa
Journal:  Immunology       Date:  2000-04       Impact factor: 7.397

7.  Correlation of anti-cytoskeleton antibody activities in synovial fluid with interleukin-6 in patients with osteoarthritis and inflammatory joint disease.

Authors:  W J Mayet; E Hermann; M Bachmann; M Manns; K H Meyer zum Büschenfelde
Journal:  Klin Wochenschr       Date:  1990-07-05

8.  Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats.

Authors:  S Carlsén; A S Hansson; H Olsson; D Heinegård; R Holmdahl
Journal:  Clin Exp Immunol       Date:  1998-12       Impact factor: 4.330

9.  Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice.

Authors:  Fumiaki Kojima; Mohit Kapoor; Lihua Yang; Erica L Fleishaker; Martin R Ward; Seetha U Monrad; Ponnappa C Kottangada; Charles Q Pace; James A Clark; Jerold G Woodward; Leslie J Crofford
Journal:  J Immunol       Date:  2008-06-15       Impact factor: 5.422

10.  Incidence of antibodies to native and denatured cartilage collagens (types II, IX, and XI) and to type I collagen in rheumatoid arthritis.

Authors:  K Morgan; R B Clague; I Collins; S Ayad; S D Phinn; P J Holt
Journal:  Ann Rheum Dis       Date:  1987-12       Impact factor: 19.103
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