Literature DB >> 6095841

Synergism between A23187 and 1-oleoyl-2-acetyl-glycerol in superoxide production by human neutrophils.

A Penfield, M M Dale.   

Abstract

Concentrations of the calcium ionophore A23187 and 1-oleoyl-2-acetyl-glycerol, which on their own are minimally effective in stimulating superoxide release from human neutrophils, show marked mutual potentiation when given simultaneously. The potentiating effect of the diacylglycerol can be shown to be dose-related. These results support the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in signal transduction for the respiratory burst in the human neutrophil.

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Year:  1984        PMID： 6095841     DOI： 10.1016/s0006-291x(84)80372-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils.

Authors:  M M Dale; A Penfield
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

Review 2.  Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium.

Authors:  P G Heyworth; J A Badwey
Journal:  J Bioenerg Biomembr       Date:  1990-02       Impact factor: 2.945

3.  Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.

Authors:  L C McPhail; P S Shirley; C C Clayton; R Snyderman
Journal:  J Clin Invest       Date:  1985-05       Impact factor: 14.808

4.  Relationship of superoxide production to cytoplasmic free calcium in human monocytes.

Authors:  S P Scully; G B Segel; M A Lichtman
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808

5.  The temporal relationship between phospholipase activation, diradylglycerol formation and superoxide production in the human neutrophil.

Authors:  N T Thompson; J E Tateson; R W Randall; G D Spacey; R W Bonser; L G Garland
Journal:  Biochem J       Date:  1990-10-01       Impact factor: 3.857

6.  Agonist-induced calcium flux, phosphoinositide metabolism, aggregation and enzyme secretion in human neutrophils.

Authors:  A G Rossi; R M McMillan; D E MacIntyre
Journal:  Agents Actions       Date:  1988-07

Review 7.  The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis.

Authors:  N C Smith
Journal:  Parasitol Res       Date:  1989       Impact factor: 2.289

8.  A role for protein kinase C in the production of free oxygen radicals in response to Nippostrongylus brasiliensis.

Authors:  N C Smith
Journal:  Parasitol Res       Date:  1991       Impact factor: 2.289

9.  Cell surface expression of fMet-Leu-Phe receptors on human neutrophils. Correlation to changes in the cytosolic free Ca2+ level and action of phorbol myristate acetate.

Authors:  T Andersson; C Dahlgren; P D Lew; O Stendahl
Journal:  J Clin Invest       Date:  1987-04       Impact factor: 14.808

10.  Function and stimulus-specific effects of phorbol 12-myristate 13-acetate on human polymorphonuclear neutrophils: autoregulatory role for protein kinase C in signal transduction.

Authors:  R J Smith; J M Justen; L M Sam
Journal:  Inflammation       Date:  1988-12       Impact factor: 4.092
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