Literature DB >> 6095733

Phenytoin interacts with calcium channels in brain membranes.

D A Greenberg, E C Cooper, C L Carpenter.   

Abstract

Phenytoin at concentrations of between 30 and 300 microM inhibited binding of the calcium antagonist [3H] nitrendipine to voltage-dependent calcium channels in brain membranes. Other anticonvulsants (phenobarbital, carbamazepine, valproic acid, and clonazepam) failed to inhibit binding or did so only at concentrations much higher than occur clinically. Calcium channel blockade may be important in the clinical actions of phenytoin, including certain of the adverse effects of the drug.

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Year:  1984        PMID： 6095733     DOI： 10.1002/ana.410160514

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  4 in total

1.  Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia.

Authors:  R E Westenbroek; S B Bausch; R C Lin; J E Franck; J L Noebels; W A Catterall
Journal:  J Neurosci       Date:  1998-04-01       Impact factor: 6.167

2.  Anticonvulsant effects of some calcium entry blockers in DBA/2 mice.

Authors:  G B De Sarro; B S Meldrum; G Nisticó
Journal:  Br J Pharmacol       Date:  1988-02       Impact factor: 8.739

3.  Discrimination reversal conditioning of an eyeblink response is impaired by NMDA receptor blockade.

Authors:  J D Churchill; J T Green; S E Voss; E Manley; J E Steinmetz; P E Garraghty
Journal:  Integr Physiol Behav Sci       Date:  2001 Jan-Mar

4.  Nifedipine in the treatment of myotonia in myotonic dystrophy.

Authors:  R Grant; D L Sutton; P O Behan; J P Ballantyne
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-02       Impact factor: 10.154
  4 in total

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