Literature DB >> 6095184

Kinetoplast DNA minicircles of trypanosomatids encode for a protein product.

J Shlomai, A Zadok.   

Abstract

The major constituent of the trypanosomal kinetoplast DNA network are several thousand duplex DNA minicircles whose biological function is still unknown. The coding capacity and expression of these DNA minicircles, was studied in the trypanosomatid Crithidia fasciculata. Kinetoplast DNA minicircle fragments inserted into bacterial plasmid vectors were expressed in the bacterial cell. Sera elicited in rabbits, by immunization with the translational products of kinetoplast DNA minicircles in E. coli, reacted specifically with Crithidia fasciculata cellular antigens. It is inferred that kinetoplast DNA minicircles contain long open reading frames of nucleotides which are expressed in the trypanosomatid cell.

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Year:  1984        PMID： 6095184      PMCID： PMC320267          DOI： 10.1093/nar/12.21.8017

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  21 in total

1.  Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.

Authors:  R A Laskey; A D Mills
Journal:  Eur J Biochem       Date:  1975-08-15

2.  Sequence heterogeneity of the mini-circles of kinetoplast DNA of Crithidia luciliae and evidence for the presence of a component more complex than mini-circle DNA in the kinetoplast network.

Authors:  C M Kleisen; P Borst
Journal:  Biochim Biophys Acta       Date:  1975-11-04

3.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

4.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

Review 5.  Kinetoplast DNA.

Authors:  P Borst; J H Hoeijmakers
Journal:  Plasmid       Date:  1979-01       Impact factor: 3.466

6.  The cross-linking of proteins with glutaraldehyde and its use for the preparation of immunoadsorbents.

Authors:  S Avrameas; T Ternynck
Journal:  Immunochemistry       Date:  1969-01

7.  [Study of kinetoplast DNA of Trypansoma cruzi using restriction endonucleases].

Authors:  G Riou; P Yot
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1975-06-16

8.  RNA from the insect trypanosome Crithidia luciliae contains transcripts of the maxi-circle and not of the mini-circle component of kinetoplast DNA.

Authors:  J H Hoeijmakers; P Borst
Journal:  Biochim Biophys Acta       Date:  1978-11-21

9.  Isolation and characterization of kinetoplast DNA networks and minicircles from Crithidia fasciculata.

Authors:  A M Simpson; L Simpson
Journal:  J Protozool       Date:  1974-11

10.  Kinetoplast RNA of Leishmania tarentolae.

Authors:  L Simpson; A G Simpson
Journal:  Cell       Date:  1978-05       Impact factor: 41.582
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  4 in total

1.  The divergent region of the Leishmania tarentolae kinetoplast maxicircle DNA contains a diverse set of repetitive sequences.

Authors:  M L Muhich; N Neckelmann; L Simpson
Journal:  Nucleic Acids Res       Date:  1985-05-10       Impact factor: 16.971

2.  Specific cleavage of kinetoplast minicircle DNA from Leishmania tarentolae by mung bean nuclease and identification of several additional minicircle sequence classes.

Authors:  M L Muhich; L Simpson
Journal:  Nucleic Acids Res       Date:  1986-07-11       Impact factor: 16.971

3.  Differential expression of mitochondrial genes between life cycle stages of Trypanosoma brucei.

Authors:  J E Feagin; K Stuart
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

4.  Kinetoplast DNA of Bodo caudatus: a noncatenated structure.

Authors:  S L Hajduk; A M Siqueira; K Vickerman
Journal:  Mol Cell Biol       Date:  1986-12       Impact factor: 4.272
  4 in total

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